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Sci. Signal., 3 March 2009
Vol. 2, Issue 60, p. ra9
To Shape a Smell?
Our ability to detect and discriminate among the numerous odorous compounds to which we are exposed depends on odorant recognition by members of a large family of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled odorant receptors (ORs). However, the specific physicochemical properties that enable a particular odorant to act as a ligand for a particular receptor—and thus the initial stage in determining how that odorant is perceived—remain unclear. Saito et al. used a heterologous expression system to test the responses of a large library of human and mouse ORs with a panel of 93 odorants. Analysis of ligand properties and OR sequences enabled the authors to develop a model for predicting interactions between ORs and their ligands.
Citation: H. Saito, Q. Chi, H. Zhuang, H. Matsunami, J. D. Mainland, Odor Coding by a Mammalian Receptor Repertoire. Sci. Signal.2, ra9 (2009).
Chemosensory Ca2+ Dynamics Correlate with Diverse Behavioral Phenotypes in Human Sperm.
T. Veitinger, J. R. Riffell, S. Veitinger, J. M. Nascimento, A. Triller, C. Chandsawangbhuwana, K. Schwane, A. Geerts, F. Wunder, M. W. Berns, et al. (2011)
J. Biol. Chem.
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Activation State of the M3 Muscarinic Acetylcholine Receptor Modulates Mammalian Odorant Receptor Signaling.