Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 17 March 2009
Vol. 2, Issue 62, p. ra11
[DOI: 10.1126/scisignal.2000143]

RESEARCH ARTICLES

Editor's Summary

Akting on the Vasculature
Although obesity is a well-known risk factor for cardiovascular disease, the signals that connect the two remain unclear. Noting that aberrant signaling involving mammalian target of rapamycin (mTOR) and Akt has been linked to obesity and its pathophysiological complications and that both of these kinases have been implicated in development of cellular senescence, Wang et al. explored the roles of Akt and mTOR in endothelial cell senescence. They showed that increased endothelial Akt signaling linked a high-fat diet to increased endothelial cell senescence and vascular dysfunction in mice. Intriguingly, the mTOR inhibitor rapamycin inhibited the long-term activation of endothelial Akt, as well as vascular cell senescence, and ameliorated the vascular sequelae of ischemia. The authors thus propose that inhibition of Akt activation with rapamycin therapy may have clinical benefits in obesity-related cardiovascular disease.

Citation: C.-Y. Wang, H.-H. Kim, Y. Hiroi, N. Sawada, S. Salomone, L. E. Benjamin, K. Walsh, M. A. Moskowitz, J. K. Liao, Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR. Sci. Signal. 2, ra11 (2009).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease.
S. Sciarretta, M. Volpe, and J. Sadoshima (2014)
Circ. Res. 114, 549-564
   Abstract »    Full Text »    PDF »
Aging Exacerbates Obesity-Induced Oxidative Stress and Inflammation in Perivascular Adipose Tissue in Mice: A Paracrine Mechanism Contributing to Vascular Redox Dysregulation and Inflammation.
L. C. Bailey-Downs, Z. Tucsek, P. Toth, D. Sosnowska, T. Gautam, W. E. Sonntag, A. Csiszar, and Z. Ungvari (2013)
J Gerontol A Biol Sci Med Sci 68, 780-792
   Abstract »    Full Text »    PDF »
Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia: Pathophysiological Implications in Obesity and Metabolic Syndrome.
S. Sciarretta, P. Zhai, D. Shao, Y. Maejima, J. Robbins, M. Volpe, G. Condorelli, and J. Sadoshima (2012)
Circulation 125, 1134-1146
   Abstract »    Full Text »    PDF »
Insulin Resistance Impairs Circulating Angiogenic Progenitor Cell Function and Delays Endothelial Regeneration.
M. B. Kahn, N. Y. Yuldasheva, R. M. Cubbon, J. Smith, S. T. Rashid, H. Viswambharan, H. Imrie, A. Abbas, A. Rajwani, A. Aziz, et al. (2011)
Diabetes 60, 1295-1303
   Abstract »    Full Text »    PDF »
De Novo Lipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation.
X. Wei, J. G. Schneider, S. M. Shenouda, A. Lee, D. A. Towler, M. V. Chakravarthy, J. A. Vita, and C. F. Semenkovich (2011)
J. Biol. Chem. 286, 2933-2945
   Abstract »    Full Text »    PDF »
Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence.
A. Villaret, J. Galitzky, P. Decaunes, D. Esteve, M.-A. Marques, C. Sengenes, P. Chiotasso, T. Tchkonia, M. Lafontan, J. L. Kirkland, et al. (2010)
Diabetes 59, 2755-2763
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 5 January 2010.
M. B. Yaffe and A. M. VanHook (2010)
Science Signaling 3, pc1
   Abstract »    Full Text »
The Akt1-eNOS Axis Illustrates the Specificity of Kinase-Substrate Relationships in Vivo.
M. Schleicher, J. Yu, T. Murata, B. Derakhshan, D. Atochin, L. Qian, S. Kashiwagi, A. Di Lorenzo, K. D. Harrison, P. L. Huang, et al. (2009)
Science Signaling 2, ra41
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 21 April 2009.
M. B. Yaffe and A. M. VanHook (2009)
Science Signaling 2, pc8
   Abstract »    Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882