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Sci. Signal., 7 April 2009
Vol. 2, Issue 65, p. ra15
[DOI: 10.1126/scisignal.2000199]

RESEARCH ARTICLES

Editor's Summary

Right Times and Right Places
Signals downstream of receptor activation can be effectively regulated by controlling both the distribution of signaling intermediates within the cell and the time at which they get to their destinations. Such spatiotemporal patterning of receptors, kinases, and adaptor molecules can have a substantial effect on their local concentrations and on the probabilities that they will interact with each other. Previous studies have characterized the patterning of individual or small groups of molecules; however, systems-level analyses of such processes are lacking. Singleton et al. have studied the spatiotemporal patterning of some 30 signaling intermediates in various mouse T cells activated by antigen-presenting cells under different conditions. As well as establishing that the patterning of these molecules regulates the efficiency of T cell receptor signaling, this study also shows that different T cell activation conditions generate different spatiotemporal patterns.

Citation: K. L. Singleton, K. T. Roybal, Y. Sun, G. Fu, N. R. J. Gascoigne, N. S. C. van Oers, C. Wülfing, Spatiotemporal Patterning During T Cell Activation Is Highly Diverse. Sci. Signal. 2, ra15 (2009).

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