Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Signal., 28 April 2009
Vol. 2, Issue 68, p. ra19
[DOI: 10.1126/scisignal.2000102]

RESEARCH ARTICLES

Editor's Summary

Patterning Postsynaptic Phosphorylation
The postsynaptic density of excitatory synapses in the mammalian brain—the initial site for integration of incoming information from the presynaptic neuron—contains over a thousand different proteins. Rather than investigating the effects of neurotransmitter signaling on a single pathway, Coba et al. explored the functional organization of these postsynaptic density proteins. Using a large-scale proteomic approach, they found that stimulation of different classes of neurotransmitter receptor affected the phosphorylation status of hundreds of phosphorylation sites in overlapping networks of postsynaptic density proteins. Identification of a set of regulatory phosphorylation motifs enabled them to construct a model of the molecular circuitry of the postsynaptic proteome, a crucial step in elucidating how postsynaptic neurons process incoming information.

Citation: M. P. Coba, A. J. Pocklington, M. O. Collins, M. V. Kopanitsa, R. T. Uren, S. Swamy, M. D. R. Croning, J. S. Choudhary, S. G. N. Grant, Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks. Sci. Signal. 2, ra19 (2009).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biochemical Fractionation and Stable Isotope Dilution Liquid Chromatography-mass Spectrometry for Targeted and Microdomain-specific Protein Quantification in Human Postmortem Brain Tissue.
M. L. MacDonald, E. Ciccimaro, A. Prakash, A. Banerjee, S. H. Seeholzer, I. A. Blair, and C.-G. Hahn (2012)
Mol. Cell. Proteomics 11, 1670-1681
   Abstract »    Full Text »    PDF »
TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function.
M. P. Coba, N. H. Komiyama, J. Nithianantharajah, M. V. Kopanitsa, T. Indersmitten, N. G. Skene, E. J. Tuck, D. G. Fricker, K. A. Elsegood, L. E. Stanford, et al. (2012)
J. Neurosci. 32, 13987-13999
   Abstract »    Full Text »    PDF »
The DPY-30 Domain and Its Flanking Sequence Mediate the Assembly and Modulation of Flagellar Radial Spoke Complexes.
R. Gopal, K. W. Foster, and P. Yang (2012)
Mol. Cell. Biol. 32, 4012-4024
   Abstract »    Full Text »    PDF »
NMDA Receptor Hypofunction Induces Dysfunctions of Energy Metabolism And Semaphorin Signaling in Rats: A Synaptic Proteome Study.
K. Zhou, Y. Yang, L. Gao, G. He, W. Li, K. Tang, B. Ji, M. Zhang, Y. Li, J. Yang, et al. (2012)
Schizophr Bull 38, 579-591
   Abstract »    Full Text »    PDF »
Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.
L. Xue, W.-H. Wang, A. Iliuk, L. Hu, J. A. Galan, S. Yu, M. Hans, R. L. Geahlen, and W. A. Tao (2012)
PNAS 109, 5615-5620
   Abstract »    Full Text »    PDF »
The Postsynaptic Organization of Synapses.
M. Sheng and E. Kim (2011)
Cold Spring Harb Perspect Biol 3, a005678
   Abstract »    Full Text »    PDF »
Neuroprotective role of PrPC against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7-PSD-95 binding.
P. Carulla, A. Bribian, A. Rangel, R. Gavin, I. Ferrer, C. Caelles, J. A. del Rio, and F. Llorens (2011)
Mol. Biol. Cell 22, 3041-3054
   Abstract »    Full Text »    PDF »
Functional NMDA receptors with atypical properties are expressed in podocytes.
M. Anderson, J. M. Suh, E. Y. Kim, and S. E. Dryer (2011)
Am J Physiol Cell Physiol 300, C22-C32
   Abstract »    Full Text »    PDF »
In Vivo Composition of NMDA Receptor Signaling Complexes Differs between Membrane Subdomains and Is Modulated by PSD-95 And PSD-93.
I. Delint-Ramirez, E. Fernandez, A. Bayes, E. Kicsi, N. H. Komiyama, and S. G. N. Grant (2010)
J. Neurosci. 30, 8162-8170
   Abstract »    Full Text »    PDF »
A General Basis for Cognition in the Evolution of Synapse Signaling Complexes.
S.G.N. Grant (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Science Signaling Podcast: 28 July 2009.
M. B. Yaffe and A. M. VanHook (2009)
Science Signaling 2, pc14
   Abstract »    Full Text »
The Complexity of Cell Signaling and the Need for a New Mechanics.
W. S. Hlavacek and J. R. Faeder (2009)
Science Signaling 2, pe46
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882