Jump to: Page Content, Section Navigation, Site Navigation, Site Search, Account Information, or Site Tools.
|
|
Sci. Signal., 26 May 2009 RESEARCHEditor's Summary BTK Checks Wnt–β-Catenin–Mediated Gene ExpressionDysregulated Wnt signaling is associated with several human diseases. James et al. now connect the Wnt–β-catenin pathway to Brutons tyrosine kinase, which is encoded by the gene responsible for X-linked agammaglobulinemia, a disease associated with decreased ability to fight infection due to a deficiency in B cells. By combining a small-molecule screen with a targeted siRNA screen, BTK was identified as an inhibitor of β-catenin–mediated gene expression. BTK did not alter the abundance of β-catenin in the presence or absence of Wnt; instead, it appeared to influence the stability of CDC73, a constituent of the PAF elongation complex and known binding partner of β-catenin. In B cells, CDC73 also inhibited β-catenin–mediated gene expression and BTK may act through this nuclear protein to restrain β-catenins transcriptional activity.
Citation: R. G. James, T. L. Biechele, W. H. Conrad, N. D. Camp, D. M. Fass, M. B. Major, K. Sommer, X. Yi, B. S. Roberts, M. A. Cleary, W. T. Arthur, M. MacCoss, D. J. Rawlings, S. J. Haggarty, R. T. Moon, Brutons Tyrosine Kinase Revealed as a Negative Regulator of Wnt–β-Catenin Signaling. Sci. Signal. 2, ra25 (2009). The editors suggest the following Related Resources on Science sites:In Science Signaling
|
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882