Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 21 July 2009
Vol. 2, Issue 80, p. ra37
[DOI: 10.1126/scisignal.1162191]

RESEARCH ARTICLES

Editor's Summary

Selective Inhibition
Interferon-{gamma} (IFN-{gamma}) activates the Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway to stimulate the production of the proinflammatory mediators that are required for an appropriate immune response. Defects in a required negative regulatory mechanism mediated by suppressor of cytokine signaling (SOCS) proteins are implicated in chronic inflammatory conditions. DiGiandomenico et al. engineered a cell-penetrating form of SOCS1 (CP-SOCS1) expressed in a human cell line that specifically targeted STAT1 to block IFN-{gamma}–induced production of proinflammatory cytokines and chemokines by macrophages. The application of cell-penetrating proteins produced in human cells has advantages both for research and for potential clinical applications over recombinant proteins purified from bacteria. In addition, CP-SOCS1 may provide a therapeutic strategy against inflammatory diseases.

Citation: A. DiGiandomenico, L. S. Wylezinski, J. Hawiger, Intracellular Delivery of a Cell-Penetrating SOCS1 that Targets IFN-{gamma} Signaling. Sci. Signal. 2, ra37 (2009).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Interferon-{gamma} biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells.
R. Satou, K. Miyata, R. A. Gonzalez-Villalobos, J. R. Ingelfinger, L. G. Navar, and H. Kobori (2012)
FASEB J 26, 1821-1830
   Abstract »    Full Text »    PDF »
A new experimental murine model for lipopolysaccharide-mediated lethal shock with lung injury.
T. Yokochi (2012)
Innate Immunity 18, 364-370
   Abstract »    Full Text »    PDF »
Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation.
S. Bhattacharyya, Y. Zhao, T. W. H. Kay, and L. J. Muglia (2011)
PNAS 108, 9554-9559
   Abstract »    Full Text »    PDF »
Extended Anti-inflammatory Action of a Degradation-resistant Mutant of Cell-penetrating Suppressor of Cytokine Signaling 3.
T. C. Fletcher, A. DiGiandomenico, and J. Hawiger (2010)
J. Biol. Chem. 285, 18727-18736
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882