Sci. Signal., 1 September 2009
Inflammatory ProliferationBoth embryonic development and response to inflammation and injury are characterized by the proliferation of epithelial and progenitor cells and remodeling of the tissue stroma. Moreover, signaling pathways involved in development are reactivated during wound healing. Jerde and Bushman investigated the reverse scenario and found that the inflammatory cytokine interleukin-1 (IL-1) stimulated epithelial cell growth in the developing prostate. Their data suggest that IL-1 family cytokines produced by epithelial cells act on stromal cells to stimulate insulin-like growth factor production, which in turn acts on epithelial cells to stimulate their proliferation. Noting that both inflammation and reactivation of developmental signaling pathways are associated with adenocarcinomas—another condition associated with epithelial and progenitor cell proliferation and stromal remodeling—the authors speculate that inflammatory mediators may play a conserved role in promoting epithelial proliferation in all of these conditions.
Citation: T. J. Jerde, W. Bushman, IL-1 Induces IGF-Dependent Epithelial Proliferation in Prostate Development and Reactive Hyperplasia. Sci. Signal. 2, ra49 (2009).
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