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Sci. Signal., 15 September 2009
Vol. 2, Issue 88, p. ra54
Localized formation of reactive oxygen species (ROS) by NADPH oxidase (Nox) complexes is crucial to various physiological and pathological processes; however, the mechanisms targeting ROS production to particular cellular locales have been unclear. Here, Gianni et al. identify Tks4 and Tks5 as members of a family of organizer proteins that regulate assembly of the Nox complex in response to various signals. They found that Tks4 and Tks5 supported ROS production by Nox1 and Nox3 and that, in a line of human colon cancer cells, Nox1 localized to invadopodia, actin-rich structures that facilitate degradation of the extracellular matrix and cancer invasion. Furthermore, Tks4 was critical to Nox1-dependent ROS production by these cells and in their ability to degrade the extracellular matrix. The authors thus propose that Tks4 targets Nox1 to invadopodia and, more generally, that Tks organizer proteins may play an important role in the localized ROS production by Nox complexes.
Citation: D. Gianni, B. Diaz, N. Taulet, B. Fowler, S. A. Courtneidge, G. M. Bokoch, Novel p47phox-Related Organizers Regulate Localized NADPH Oxidase 1 (Nox1) Activity. Sci. Signal.2, ra54 (2009).