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Sci. Signal., 29 September 2009
Vol. 2, Issue 90, p. ra58
[DOI: 10.1126/scisignal.2000213]


Editor's Summary

Exploiting the Host’s Phosphatases
Leishmaniasis is a globally important infectious disease caused by the parasite Leishmania. Gomez et al. show that infection of macrophages with Leishmania alters the activity of multiple protein tyrosine phosphatases (PTPs) through cleavage mediated by the parasite protein GP63. The activated PTPs inhibit macrophage inflammatory immune responses through dephosphorylation of Janus kinases. In addition to the PTP SHP-1, previously reported to be activated in response to Leishmania infection, Gomez et al. show that the PTPs TCPTP and PTP1B are also activated and that PTP1B serves a key role in the initial stages of disease progression in mice.

Citation: M. A. Gomez, I. Contreras, M. Hallé, M. L. Tremblay, R. W. McMaster, M. Olivier, Leishmania GP63 Alters Host Signaling Through Cleavage-Activated Protein Tyrosine Phosphatases. Sci. Signal. 2, ra58 (2009).

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Programmed Death 1-Mediated T Cell Exhaustion during Visceral Leishmaniasis Impairs Phagocyte Function.
K. J. Esch, R. Juelsgaard, P. A. Martinez, D. E. Jones, and C. A. Petersen (2013)
J. Immunol. 191, 5542-5550
   Abstract »    Full Text »    PDF »
Deficiency in Hematopoietic Phosphatase Ptpn6/Shp1 Hyperactivates the Innate Immune System and Impairs Control of Bacterial Infections in Zebrafish Embryos.
Z. Kanwal, A. Zakrzewska, J. den Hertog, H. P. Spaink, M. J. M. Schaaf, and A. H. Meijer (2013)
J. Immunol. 190, 1631-1645
   Abstract »    Full Text »    PDF »
The Protein Tyrosine Phosphatase SHP-1 Regulates Phagolysosome Biogenesis.
C. P. Gomez, M. Tiemi Shio, P. Duplay, M. Olivier, and A. Descoteaux (2012)
J. Immunol. 189, 2203-2210
   Abstract »    Full Text »    PDF »
Secreted virulence factors and immune evasion in visceral leishmaniasis.
U. Lambertz, J. M. Silverman, D. Nandan, W. R. McMaster, J. Clos, L. J. Foster, and N. E. Reiner (2012)
J. Leukoc. Biol. 91, 887-899
   Abstract »    Full Text »    PDF »
Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species.
F. Raymond, S. Boisvert, G. Roy, J.-F. Ritt, D. Legare, A. Isnard, M. Stanke, M. Olivier, M. J. Tremblay, B. Papadopoulou, et al. (2012)
Nucleic Acids Res. 40, 1131-1147
   Abstract »    Full Text »    PDF »
Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.
M. B. Rogers, J. D. Hilley, N. J. Dickens, J. Wilkes, P. A. Bates, D. P. Depledge, D. Harris, Y. Her, P. Herzyk, H. Imamura, et al. (2011)
Genome Res. 21, 2129-2142
   Abstract »    Full Text »    PDF »
Leishmania donovani Amastigotes Impair Gamma Interferon-Induced STAT1{alpha} Nuclear Translocation by Blocking the Interaction between STAT1{alpha} and Importin-{alpha}5.
C. Matte and A. Descoteaux (2010)
Infect. Immun. 78, 3736-3743
   Abstract »    Full Text »    PDF »
Editorial: Leishmania survival mechanisms: the role of host phosphatases.
M. T. Shio and M. Olivier (2010)
J. Leukoc. Biol. 88, 1-3
   Full Text »    PDF »
Comparative Study of the Ability of Leishmania mexicana Promastigotes and Amastigotes To Alter Macrophage Signaling and Functions.
I. Abu-Dayyeh, K. Hassani, E. R. Westra, J. C. Mottram, and M. Olivier (2010)
Infect. Immun. 78, 2438-2445
   Abstract »    Full Text »    PDF »

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