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Sci. Signal., 29 September 2009
Vol. 2, Issue 90, p. ra58
[DOI: 10.1126/scisignal.2000213]

RESEARCH ARTICLES

Editor's Summary

Exploiting the Host’s Phosphatases
Leishmaniasis is a globally important infectious disease caused by the parasite Leishmania. Gomez et al. show that infection of macrophages with Leishmania alters the activity of multiple protein tyrosine phosphatases (PTPs) through cleavage mediated by the parasite protein GP63. The activated PTPs inhibit macrophage inflammatory immune responses through dephosphorylation of Janus kinases. In addition to the PTP SHP-1, previously reported to be activated in response to Leishmania infection, Gomez et al. show that the PTPs TCPTP and PTP1B are also activated and that PTP1B serves a key role in the initial stages of disease progression in mice.

Citation: M. A. Gomez, I. Contreras, M. Hallé, M. L. Tremblay, R. W. McMaster, M. Olivier, Leishmania GP63 Alters Host Signaling Through Cleavage-Activated Protein Tyrosine Phosphatases. Sci. Signal. 2, ra58 (2009).

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Comparative Study of the Ability of Leishmania mexicana Promastigotes and Amastigotes To Alter Macrophage Signaling and Functions.
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