Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 29 September 2009
Vol. 2, Issue 90, p. ra59
[DOI: 10.1126/scisignal.2000300]
RESEARCH ARTICLES
Editor's Summary
Apoptosis, With or Without Hippo
The Hippo signaling pathway, named after the kinase Hippo, limits organ size without affecting patterning, and the components of this pathway are conserved from Drosophila to mammals. Drosophila RASSF (Ras association domain family) not only inhibits Hippo signaling and thus counters Hippo-mediated apoptosis, but also exhibits tumor suppressor function. Of the 10 mammalian RASSF isoforms, the best-characterized isoform, RASSF1A, activates the mammalian homologs of Hippo (the MST kinases), which contrasts with the role of dRASSF. Ikeda et al. show that RASSF6 represents another twist in the RASSF protein family. RASSF6 and MST2 are mutual inhibitors: Activation of MST2 disrupted binding of RASSF6 to MST2, enabling MST2 to induce apoptosis through a process dependent on the Hippo pathway and allowing RASSF6 to mediate apoptosis through a Hippo-independent pathway. These results suggest that mammalian RASSF isoforms may have divergent functions and may link the Hippo pathway to other signal transduction cascades.
Citation: M. Ikeda, A. Kawata, M. Nishikawa, Y. Tateishi, M. Yamaguchi, K. Nakagawa, S. Hirabayashi, Y. Bao, S. Hidaka, Y. Hirata, Y. Hata, Hippo Pathway–Dependent and –Independent Roles of RASSF6. Sci. Signal.2, ra59 (2009).
The editors suggest the following Related Resources on Science sites:
In Science Signaling
EDITORS' CHOICE
L. Bryan Ray (21 May 2013) Sci. Signal.6 (276), ec115.
[DOI: 10.1126/scisignal.2004332] |Abstract »
PERSPECTIVES
Emad Heidary Arash and Liliana Attisano (14 May 2013) Sci. Signal.6 (275), pe18.
[DOI: 10.1126/scisignal.2004259] |Abstract »|Full Text »|PDF »
EDITORS' CHOICE
Annalisa M. VanHook (19 March 2013) Sci. Signal.6 (267), ec67.
[DOI: 10.1126/scisignal.2004151] |Abstract »
EDITORS' CHOICE
Wei Wong (22 November 2011) Sci. Signal.4 (200), ec322.
[DOI: 10.1126/scisignal.4200ec322] |Abstract »
PODCASTS
James F. Martin, Valeri Vasioukhin, Mark R. Silvis, and Annalisa M. VanHook (24 May 2011) Sci. Signal.4 (174), pc10.
[DOI: 10.1126/scisignal.2002177] |Abstract »|Full Text »|Podcast »
RESEARCH ARTICLES
Mark R. Silvis, Bridget T. Kreger, Wen-Hui Lien, Olga Klezovitch, G. Marianna Rudakova, Fernando D. Camargo, Dan M. Lantz, John T. Seykora, and Valeri Vasioukhin (24 May 2011) Sci. Signal.4 (174), ra33.
[DOI: 10.1126/scisignal.2001823] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
EDITORS' CHOICE
Annalisa M. VanHook (26 April 2011) Sci. Signal.4 (170), ec117.
[DOI: 10.1126/scisignal.4170ec117] |Abstract »
EDITORS' CHOICE
John F. Foley (31 August 2010) Sci. Signal.3 (137), ec266.
[DOI: 10.1126/scisignal.3137ec266] |Abstract »
EDITORS' CHOICE
Wei Wong (2 March 2010) Sci. Signal.3 (111), ec67.
[DOI: 10.1126/scisignal.3111ec67] |Abstract »
EDITORIAL GUIDES
Annalisa M. VanHook (9 December 2008) Sci. Signal.1 (49), eg10.
[DOI: 10.1126/scisignal.149eg10] |Abstract »|Full Text »|PDF »
EDITORS' CHOICE
John F. Foley (18 March 2008) Sci. Signal.1 (11), ec100.
[DOI: 10.1126/stke.111ec100] |Abstract »
PERSPECTIVES
Feng Yin and Duojia Pan (3 April 2007) Sci. STKE2007 (380), pe12.
[DOI: 10.1126/stke.3802007pe12] |Abstract »|Full Text »|PDF »
Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells.
K. Withanage, K. Nakagawa, M. Ikeda, H. Kurihara, T. Kudo, Z. Yang, A. Sakane, T. Sasaki, and Y. Hata (2012)
J. Biochem.
152, 111-119
|Abstract »|Full Text »|PDF »
The RASSF3 Candidate Tumor Suppressor Induces Apoptosis and G1-S Cell-Cycle Arrest via p53.
T. Kudo, M. Ikeda, M. Nishikawa, Z. Yang, K. Ohno, K. Nakagawa, and Y. Hata (2012)
Cancer Res.
72, 2901-2911
|Abstract »|Full Text »|PDF »
A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription.
Y. Bao, K. Nakagawa, Z. Yang, M. Ikeda, K. Withanage, M. Ishigami-Yuasa, Y. Okuno, S. Hata, H. Nishina, and Y. Hata (2011)
J. Biochem.
150, 199-208
|Abstract »|Full Text »|PDF »
The growing role of the Hippo-NDR kinase signalling in neuronal development and disease.
Tumor Suppressor Ras Association Domain Family 5 (RASSF5/NORE1) Mediates Death Receptor Ligand-induced Apoptosis.
J. Park, S. I. Kang, S.-Y. Lee, X. F. Zhang, M. S. Kim, L. F. Beers, D.-S. Lim, J. Avruch, H.-S. Kim, and S. B. Lee (2010)
J. Biol. Chem.
285, 35029-35038
|Abstract »|Full Text »|PDF »
Mammalian Ste20-like Kinase (Mst2) Indirectly Supports Raf-1/ERK Pathway Activity via Maintenance of Protein Phosphatase-2A Catalytic Subunit Levels and Consequent Suppression of Inhibitory Raf-1 Phosphorylation.
