Sci. Signal., 24 November 2009
No Assembly RequiredThe second messenger inositol trisphosphate (IP3) acts on IP3 receptors (IP3Rs) in the endoplasmic reticulum (ER) membrane to elicit Ca2+ release from intracellular stores, enabling the generation of intracellular Ca2+ signals from extracellular messengers. The regulation of these Ca2+ signals depends on the clustered organization of IP3R. Using optical techniques capable of recording single-channel IP3R activity in intact mammalian cells, Smith et al. explored the dynamics of IP3-dependent Ca2+ signals and concluded that local Ca2+ signals (known as puffs) arise from preassembled clusters of IP3R rather than depending on rapid and dynamic clustering in response to the IP3 signal itself.
Citation: I. F. Smith, S. M. Wiltgen, J. Shuai, I. Parker, Ca2+ Puffs Originate from Preestablished Stable Clusters of Inositol Trisphosphate Receptors. Sci. Signal. 2, ra77 (2009).
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