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Sci. Signal., 26 January 2010
Vol. 3, Issue 106, p. ra6
The Long and Short of DAPK Binding
Calcium-bound calmodulin (CaM) binds to and activates CaM-dependent protein kinases (CaMKs); however, the precise mechanism whereby CaM binding activates CaMKs has been unclear. Here, de Diego et al. describe the crystal structure of a prototypical CaMK, death-associated protein kinase (DAPK), in a complex with CaM to determine how CaM binding regulates DAPK activity. Intriguingly, they found that the conformation of CaM, when in a complex with DAPK protein, was distinct from the conformation that it assumed when in a complex with a short CaM-binding peptide (the DAPK autoregulatory domain).
Citation: I. de Diego, J. Kuper, N. Bakalova, P. Kursula, M. Wilmanns, Molecular Basis of the Death-Associated Protein Kinase–Calcium/Calmodulin Regulator Complex. Sci. Signal.3, ra6 (2010).