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Sci. Signal., 2 February 2010
Vol. 3, Issue 107, p. ra8
[DOI: 10.1126/scisignal.2000568]
RESEARCH ARTICLES
Editor's Summary
Noncoding RNA Decoys
Steroid receptors are transcription factors that are activated by ligand binding, which allows these proteins to bind specific sequences called "response elements" in the promoters of target genes to stimulate transcription. Now, Kino et al. find that a noncoding RNA can also interact with steroid receptors and inhibit their binding to the DNA response elements, thereby repressing steroid receptor activity. The authors found that the noncoding RNA growth arrest–specific 5 (Gas5), which accumulates in cells that have been deprived of nutrients or growth factors, bound to the glucocorticoid receptor and competed with DNA glucocorticoid response elements for binding to the receptor, thereby inhibiting glucocorticoid-mediated transcription. This sensitized cells to undergo apoptosis in response to stress by preventing the glucocorticoid-mediated transcription of antiapoptotic genes. Gas5 also interacted with other steroid receptors and inhibited their transcriptional activity, suggesting that decoy RNA response elements may be a common mechanism for regulating transcription factor activity.
Citation: T. Kino, D. E. Hurt, T. Ichijo, N. Nader, G. P. Chrousos, Noncoding RNA Gas5 Is a Growth Arrest– and Starvation-Associated Repressor of the Glucocorticoid Receptor. Sci. Signal.3, ra8 (2010).
Long Noncoding RNAs in Cardiac Development and Pathophysiology.
N. Schonrock, R. P. Harvey, and J. S. Mattick (2012)
Circ. Res.
111, 1349-1362
|Abstract »|Full Text »|PDF »
The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression.
T. Derrien, R. Johnson, G. Bussotti, A. Tanzer, S. Djebali, H. Tilgner, G. Guernec, D. Martin, A. Merkel, D. G. Knowles, et al. (2012)
Genome Res.
22, 1775-1789
|Abstract »|Full Text »|PDF »
Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs.
V. A. Moran, R. J. Perera, and A. M. Khalil (2012)
Nucleic Acids Res.
40, 6391-6400
|Abstract »|Full Text »|PDF »
ZNF764 Haploinsufficiency May Explain Partial Glucocorticoid, Androgen, and Thyroid Hormone Resistance Associated with 16p11.2 Microdeletion.
T. Kino, M. G. Pavlatou, A. G. Moraitis, R. L. Nemery, M. Raygada, and C. A. Stratakis (2012)
J. Clin. Endocrinol. Metab.
97, E1557-E1566
|Abstract »|Full Text »|PDF »
miRcode: a map of putative microRNA target sites in the long non-coding transcriptome.
A. Jeggari, D. S. Marks, and E. Larsson (2012)
Bioinformatics
28, 2062-2063
|Abstract »|Full Text »|PDF »
Genome-wide determination of RNA stability reveals hundreds of short-lived noncoding transcripts in mammals.
H. Tani, R. Mizutani, K. A. Salam, K. Tano, K. Ijiri, A. Wakamatsu, T. Isogai, Y. Suzuki, and N. Akimitsu (2012)
Genome Res.
22, 947-956
|Abstract »|Full Text »|PDF »
SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer.
M. E. Askarian-Amiri, J. Crawford, J. D. French, C. E. Smart, M. A. Smith, M. B. Clark, K. Ru, T. R. Mercer, E. R. Thompson, S. R. Lakhani, et al. (2011)
RNA
17, 878-891
|Abstract »|Full Text »|PDF »
lncRNAdb: a reference database for long noncoding RNAs.
P. P. Amaral, M. B. Clark, D. K. Gascoigne, M. E. Dinger, and J. S. Mattick (2011)
Nucleic Acids Res.
39, D146-D151
|Abstract »|Full Text »|PDF »
Inhibition of Human T-Cell Proliferation by Mammalian Target of Rapamycin (mTOR) Antagonists Requires Noncoding RNA Growth-Arrest-Specific Transcript 5 (GAS5).
M. Mourtada-Maarabouni, A. M. Hasan, F. Farzaneh, and G. T. Williams (2010)
Mol. Pharmacol.
78, 19-28
|Abstract »|Full Text »|PDF »
Glucocorticoid Receptor DNA Binding Decoy Is a Gas.
