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Sci. Signal., 23 February 2010
Vol. 3, Issue 110, p. ra13
Rising from the Dead
Tissue injury causes cell death. Apoptotic cell death enables the elimination of damaged cells, clearing the way for tissue regeneration. Enzymes called caspases are activated in apoptotic cells, and Li et al. show that in addition to helping to execute the death process, caspases 3 and 7 stimulate the release of proliferation signals from dying cells. The authors found that skin wound healing and liver regeneration were compromised in mice deficient in caspase 3 or 7. Furthermore, stem or progenitor cells injected with or without irradiated cells or injected into irradiated or undamaged tissue proliferated more in the presence of irradiated cells or tissue. The authors dub the molecular events associated with death-induced proliferation the "phoenix rising" pathway, which involves the caspase-mediated activation of phospholipase A2 and the subsequent production and release of the lipid signal prostaglandin E2, a stimulator of cell proliferation.
Citation: F. Li, Q. Huang, J. Chen, Y. Peng, D. R. Roop, J. S. Bedford, C.-Y. Li, Apoptotic Cells Activate the "Phoenix Rising" Pathway to Promote Wound Healing and Tissue Regeneration. Sci. Signal.3, ra13 (2010).
Alma Zernecke, Kiril Bidzhekov, Heidi Noels, Erdenechimeg Shagdarsuren, Lin Gan, Bernd Denecke, Mihail Hristov, Thomas Köppel, Maliheh Nazari Jahantigh, Esther Lutgens, Shusheng Wang, Eric N. Olson, Andreas Schober, and Christian Weber (8 December 2009) Sci. Signal.2 (100), ra81.
[DOI: 10.1126/scisignal.2000610] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Gabriel Sollberger and Hans-Dietmar Beer (7 July 2009) Sci. Signal.2 (78), pe40.
[DOI: 10.1126/scisignal.278pe40] |Abstract »|Full Text »|PDF »