Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 6 April 2010
Vol. 3, Issue 116, p. ra27
Masters of Integrity
In order to survive and faithfully reproduce, cells must not only maintain the integrity of their genome but also regulate the expression of the encoded products, ensure the quality of the transcripts, and coordinate protein production with metabolic status. Members of the phosphatidylinositol 3-kinase–related protein kinase (PIKK) family play essential roles in the DNA- and RNA-based processes that ensure genome integrity and accurate gene expression. Izumi et al. show that the two members of the AAA+ family of proteins, RUVBL1 and RUVBL2, which form a complex involved in chromatin-based processes, also regulated the activity and abundance of all members of the PIKK family. Furthermore, through an interaction with the PIKK member SMG-1, RUVBL1 and RUVBL2 contributed to the formation of macromolecular complexes involved in nonsense-mediated decay, a process by which prematurely terminated mRNA transcripts are eliminated to ensure that potentially dangerous truncated proteins are not produced.
Citation: N. Izumi, A. Yamashita, A. Iwamatsu, R. Kurata, H. Nakamura, B. Saari, H. Hirano, P. Anderson, S. Ohno, AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay. Sci. Signal.3, ra27 (2010).
The editors suggest the following Related Resources on Science sites:
In Science Signaling
Jean Rosenbaum, Sung Hee Baek, Anindya Dutta, Walid A. Houry, Otmar Huber, Ted R. Hupp, and Pedro M. Matias (12 March 2013) Sci. Signal.6 (266), mr1.
[DOI: 10.1126/scisignal.2003906] |Abstract »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chaperone-like activity of the AAA+ proteins Rvb1 and Rvb2 in the assembly of various complexes.