Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 1 June 2010
Vol. 3, Issue 124, p. ra43
A Loss of Restraint
Growth factors, such as epidermal growth factor (EGF), bind to receptors to stimulate cell proliferation, a process critical during development and in wound healing. Dysregulation of the signaling pathways initiated by the EGF receptor (EGFR) has been implicated in cancer. Noting that aberrant expression of microRNAs, small noncoding RNAs that inhibit the expression of target genes, is common in human malignancies, Avraham et al. explored the role of microRNAs in regulating EGFR signaling. They found that EGF elicited a rapid—and transient—decrease in the abundance of a group of 23 microRNAs, thereby enabling the induction of potentially oncogenic transcription factor targets. Moreover, the abundance of this group of microRNAs was decreased in breast cancers and brain cancers with molecular lesions consistent with increased EGFR signaling. The authors conclude that, under basal conditions, this group of microRNAs restrains potentially oncogenic signaling pathways downstream of the EGFR. Their decreased abundance in cancer thus enables the dysregulated activity of oncogenic transcription factors and signaling pathways transiently activated by EGF signaling, thereby promoting the aberrant cellular behaviors associated with cancer.
Citation: R. Avraham, A. Sas-Chen, O. Manor, I. Steinfeld, R. Shalgi, G. Tarcic, N. Bossel, A. Zeisel, I. Amit, Y. Zwang, E. Enerly, H. G. Russnes, F. Biagioni, M. Mottolese, S. Strano, G. Blandino, A.-L. Børresen-Dale, Y. Pilpel, Z. Yakhini, E. Segal, Y. Yarden, EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors. Sci. Signal.3, ra43 (2010).
The editors suggest the following Related Resources on Science sites:
In Science Signaling
Leslie K. Ferrarelli (5 November 2013) Sci. Signal.6 (300), ec267.
[DOI: 10.1126/scisignal.2004877] |Abstract »
Mumtaz Y. Balkhi, O. Hans Iwenofu, Nadine Bakkar, Katherine J. Ladner, Dawn S. Chandler, Peter J. Houghton, Cheryl A. London, William Kraybill, Danilo Perrotti, Carlo M. Croce, Charles Keller, and Denis C. Guttridge (30 July 2013) Sci. Signal.6 (286), ra63.
[DOI: 10.1126/scisignal.2004177] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »