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Sci. Signal., 8 June 2010
Vol. 3, Issue 125, p. ra45
[DOI: 10.1126/scisignal.2000549]


Editor's Summary

Feedback for Function
Neutrophils migrate to sites of infection, where they kill pathogens by processes such as phagocytosis and the release of reactive oxygen species. However, activated neutrophils can also result in tissue damage and inflammatory diseases in the host; thus, a better understanding of the mechanisms that regulate neutrophil activation could help in the development of therapies that could curb their destructive side effects. Chen et al. found that neutrophils responded to a range of infectious and inflammatory signals by releasing adenosine triphosphate (ATP). In addition to its role as a cellular energy source, ATP and its metabolites function as intercellular signaling molecules by stimulating purinergic receptors. The authors found that stimulation of formyl peptide receptors (FPRs) on neutrophils triggered the release, through pannexin-1 hemichannels, of ATP that signaled in an autocrine fashion through P2Y2 receptors. Moreover, this autocrine signal was required for neutrophil activation. In addition, mice deficient in P2Y2 receptors were less capable of clearing bacteria than were their wild-type counterparts. Together, these data suggest that feedback signaling by ATP released by neutrophils contributes to their activation.

Citation: Y. Chen, Y. Yao, Y. Sumi, A. Li, U. K. To, A. Elkhal, Y. Inoue, T. Woehrle, Q. Zhang, C. Hauser, W. G. Junger, Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation. Sci. Signal. 3, ra45 (2010).

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CR1-mediated ATP Release by Human Red Blood Cells Promotes CR1 Clustering and Modulates the Immune Transfer Process.
M. I. Melhorn, A. S. Brodsky, J. Estanislau, J. A. Khoory, B. Illigens, I. Hamachi, Y. Kurishita, A. D. Fraser, A. Nicholson-Weller, E. Dolmatova, et al. (2013)
J. Biol. Chem. 288, 31139-31153
   Abstract »    Full Text »    PDF »
Pannexin 1 Channels Link Chemoattractant Receptor Signaling to Local Excitation and Global Inhibition Responses at the Front and Back of Polarized Neutrophils.
Y. Bao, Y. Chen, C. Ledderose, L. Li, and W. G. Junger (2013)
J. Biol. Chem. 288, 22650-22657
   Abstract »    Full Text »    PDF »
Physiological mechanisms for the modulation of pannexin 1 channel activity.
J. K. Sandilos and D. A. Bayliss (2012)
J. Physiol. 590, 6257-6266
   Abstract »    Full Text »    PDF »
ATP release and autocrine signaling through P2X4 receptors regulate {gamma}{delta} T cell activation.
M. Manohar, M. I. Hirsh, Y. Chen, T. Woehrle, A. A. Karande, and W. G. Junger (2012)
J. Leukoc. Biol. 92, 787-794
   Abstract »    Full Text »    PDF »
The UDP-sugar-sensing P2Y14 receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.
J. I. Sesma, S. M. Kreda, N. Steinckwich-Besancon, H. Dang, R. Garcia-Mata, T. K. Harden, and E. R. Lazarowski (2012)
Am J Physiol Cell Physiol 303, C490-C498
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 4 January 2011.
M. B. Yaffe and A. M. VanHook (2011)
Science Signaling 4, pc1
   Abstract »    Full Text »
Purinergic Control of Neutrophil Activation.
F. Grassi (2010)
J Mol Cell Biol 2, 176-177
   Abstract »    Full Text »    PDF »
Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis.
M. Kronlage, J. Song, L. Sorokin, K. Isfort, T. Schwerdtle, J. Leipziger, B. Robaye, P. B. Conley, H.-C. Kim, S. Sargin, et al. (2010)
Science Signaling 3, ra55
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