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Sci. Signal., 13 July 2010
Vol. 3, Issue 130, p. ra52
[DOI: 10.1126/scisignal.2000762]


Editor's Summary

Setting the Pace of Regeneration
The ability of tissues to regenerate is critical for organismal survival, yet all of the mechanisms regulating this complex phenomenon are unknown. Nrf2 is a member of a family of transcription factors, and without the prosurvival signaling of Nrf2, mice are sensitive to oxidative and electrophilic stresses and exhibit delays in tissue regeneration. Wakabayashi et al. connect Nrf2 to the Notch signaling pathway, which is involved in determining cell proliferation and cell fate, by showing that Nrf2 transcriptionally stimulates expression of Notch1 to establish basal Notch1 signaling. The amount of Notch1 at the time of injury appears to set the pace of liver regeneration, and forced Notch signaling in hepatocytes restored liver regeneration in Nrf2-deficient mice.

Citation: N. Wakabayashi, S. Shin, S. L. Slocum, E. S. Agoston, J. Wakabayashi, M.-K. Kwak, V. Misra, S. Biswal, M. Yamamoto, T. W. Kensler, Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration. Sci. Signal. 3, ra52 (2010).

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Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling.
N. Wakabayashi, J. J. Skoko, D. V. Chartoumpekis, S. Kimura, S. L. Slocum, K. Noda, D. L. Palliyaguru, M. Fujimuro, P. A. Boley, Y. Tanaka, et al. (2014)
Mol. Cell. Biol. 34, 653-663
   Abstract »    Full Text »    PDF »
Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching.
Y. Wei, J. Gong, R. K. Thimmulappa, B. Kosmider, S. Biswal, and E. J. Duh (2013)
PNAS 110, E3910-E3918
   Abstract »    Full Text »    PDF »
Nrf2 participates in regulating maternal hepatic adaptations to pregnancy.
Y. Zou, M. Hu, Q. Bao, J. Y. Chan, and G. Dai (2013)
J. Cell Sci. 126, 1618-1625
   Abstract »    Full Text »    PDF »
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.
B. N. Chorley, M. R. Campbell, X. Wang, M. Karaca, D. Sambandan, F. Bangura, P. Xue, J. Pi, S. R. Kleeberger, and D. A. Bell (2012)
Nucleic Acids Res. 40, 7416-7429
   Abstract »    Full Text »    PDF »
Minocycline-Preconditioned Neural Stem Cells Enhance Neuroprotection after Ischemic Stroke in Rats.
H. Sakata, K. Niizuma, H. Yoshioka, G. S. Kim, J. E. Jung, M. Katsu, P. Narasimhan, C. M. Maier, Y. Nishiyama, and P. H. Chan (2012)
J. Neurosci. 32, 3462-3473
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 20 July 2010.
M. Fainzilber and A. M. VanHook (2010)
Science Signaling 3, pc15
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