Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 24 August 2010
Vol. 3, Issue 136, p. ra63
[DOI: 10.1126/scisignal.2001059]


Editor's Summary

Receptor Rheostat
The Hedgehog signaling pathway plays essential roles in cell fate specification and tissue patterning during development. The cellular response to this morphogen is complex because cells respond both to the absence of the ligand Hedgehog and to the presence of Hedgehog, with the cellular response a function of both the concentration of Hedgehog and the ratio of the Hedgehog-bound and unbound receptor Patched. Using the fly wing imaginal disc as a model system, Casali identified a mechanism by which Patched, which is transcriptionally induced in response to Hedgehog signaling, triggers its own down-regulation to maintain the appropriate balance of bound and unbound receptors. The mechanism did not require Hedgehog signaling per se, because both constitutively active and dominant-negative forms of the receptor induced the down-regulation. However, the Patched-induced decrease in abundance did require a ubiquitination motif in the C-terminal domain and the presence of internalization-competent receptors.

Citation: A. Casali, Self-Induced Patched Receptor Down-Regulation Modulates Cell Sensitivity to the Hedgehog Morphogen Gradient. Sci. Signal. 3, ra63 (2010).

Read the Full Text

Cell fate respecification and cell division orientation drive intercalary regeneration in Drosophila wing discs.
A. Repiso, C. Bergantinos, and F. Serras (2013)
Development 140, 3541-3551
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882