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Sci. Signal., 31 August 2010
Vol. 3, Issue 137, p. rs1
[DOI: 10.1126/scisignal.2000966]


Editor's Summary

Phosphatase Specificity
Phosphorylation of proteins is a posttranslational modification that has important functional consequences in many signaling pathways. Thus, regulation of the expression and function of the kinases and phosphatases that control the extent of phosphorylation of target proteins is tightly controlled. The amount of information available about the expression profiles of phosphatase-encoding genes is relatively little compared to that of genes that encode kinases. Arimura and Yagi used data in the RefDIC database to analyze the expression of genes encoding protein tyrosine phosphatases (PTPs) in various immune cells in the mouse. In addition to identifying PTP-encoding genes whose expression was enriched in immune relative to nonimmune tissues, the authors also identified genes whose expression was specific to a given immune cell type. Further study will determine whether these genes might serve as lineage-specific markers of these cells.

Citation: Y. Arimura, J. Yagi, Comprehensive Expression Profiles of Genes for Protein Tyrosine Phosphatases in Immune Cells. Sci. Signal. 3, rs1 (2010).

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Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ.
R. Godfrey, D. Arora, R. Bauer, S. Stopp, J. P. Muller, T. Heinrich, S.-A. Bohmer, M. Dagnell, U. Schnetzke, S. Scholl, et al. (2012)
Blood 119, 4499-4511
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