Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 14 September 2010
Vol. 3, Issue 139, p. ra66
[DOI: 10.1126/scisignal.2000906]

RESEARCH ARTICLES

Editor's Summary

Ahead of Its Time
Extrinsic apoptosis is mediated by cell surface death receptor (DR) proteins, which are members of the tumor necrosis factor receptor (TNFR) superfamily, and is thought to be restricted to vertebrates. TNFR family members, such as the Fas receptor, contain death domains (DDs) through which they interact with DD-containing adaptor proteins, such as Fas-associated DD (FADD), to activate initiator caspases and trigger apoptosis. Noting that the genome of the basal chordate amphioxus Branchiostoma belcheri tsingtauense (Bbt) contains genes that encode DRs and DD-containing adaptors, Yuan et al. investigated whether extrinsic apoptotic signaling occurred in this archetypal vertebrate. They analyzed two amphioxus DD-containing proteins, BbtFADDs 1 and 2, and a previously uncharacterized DR-containing protein, BbtDR1, which triggered responses ranging from apoptosis to gene activation depending on the adaptors with which it interacted. Together, these data suggest that apoptosis mediated through DRs was established at the emergence of the chordates, at least 550 million years ago.

Citation: S. Yuan, H. Liu, M. Gu, L. Xu, S. Huang, Z. Ren, A. Xu, Characterization of the Extrinsic Apoptotic Pathway in the Basal Chordate Amphioxus. Sci. Signal. 3, ra66 (2010).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Archaic Roles of the Amphioxus NF-{kappa}B/I{kappa}B Complex in Innate Immune Responses.
S. Yuan, J. Zhang, L. Zhang, L. Huang, J. Peng, S. Huang, S. Chen, and A. Xu (2013)
J. Immunol. 191, 1220-1230
   Abstract »    Full Text »    PDF »
Functional Conservation and Innovation of Amphioxus RIP1-Mediated Signaling in Cell Fate Determination.
J. Li, S. Yuan, L. Qi, S. Huang, G. Huang, M. Yang, L. Xu, Y. Li, R. Zhang, Y. Yu, et al. (2011)
J. Immunol. 187, 3962-3971
   Abstract »    Full Text »    PDF »
The Evolution and Regulation of the Mucosal Immune Complexity in the Basal Chordate Amphioxus.
S. Huang, X. Wang, Q. Yan, L. Guo, S. Yuan, G. Huang, H. Huang, J. Li, M. Dong, S. Chen, et al. (2011)
J. Immunol. 186, 2042-2055
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882