Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 21 September 2010
Vol. 3, Issue 140, p. ra68
[DOI: 10.1126/scisignal.20001370]


Editor's Summary

Ras Radio Waves
The Ras family of small guanosine triphosphatases (GTPases) has roles in cellular proliferation and is frequently mutated in tumors. Stimulation of cells with epidermal growth factor leads to the transient activation of H-Ras at the plasma membrane, followed by an echo of this activity at the Golgi. This distinct spatiotemporal activity profile suggests that the Golgi is a passive receiver of Ras signals from the plasma membrane. Lorentzen et al. performed quantitative imaging and mathematical modeling of cells in which binding of H-Ras to GDP or GTP was decoupled from the acylation cycle that maintains its spatial organization. Regulation of H-Ras binding to GDP or GTP occurred only at the plasma membrane and not at the Golgi. Furthermore, the acylation cycle delivered active H-Ras from the plasma membrane to the Golgi, as well as from the endoplasmic reticulum to the Golgi; this latter delivery route enabled sustained H-Ras activity at the Golgi after the initial activation echo. Thus, the amount of active Ras at the Golgi is determined by activation of Ras at the plasma membrane and the endoplasmic reticulum, and the acylation cycle serves to relay activated Ras between subcellular compartments.

Citation: A. Lorentzen, A. Kinkhabwala, O. Rocks, N. Vartak, P. I. H. Bastiaens, Regulation of Ras Localization by Acylation Enables a Mode of Intracellular Signal Propagation. Sci. Signal. 3, ra68 (2010).

Read the Full Text

Ras Stabilization Through Aberrant Activation of Wnt/{beta}-Catenin Signaling Promotes Intestinal Tumorigenesis.
W.-J. Jeong, J. Yoon, J.-C. Park, S.-H. Lee, S.-H. Lee, S. Kaduwal, H. Kim, J.-B. Yoon, and K.-Y. Choi (2012)
Science Signaling 5, ra30
   Abstract »    Full Text »    PDF »
DHHC Protein S-Acyltransferases Use Similar Ping-Pong Kinetic Mechanisms but Display Different Acyl-CoA Specificities.
B. C. Jennings and M. E. Linder (2012)
J. Biol. Chem. 287, 7236-7245
   Abstract »    Full Text »    PDF »
Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan.
S. Sigismund, S. Confalonieri, A. Ciliberto, S. Polo, G. Scita, and P. P. Di Fiore (2012)
Physiol Rev 92, 273-366
   Abstract »    Full Text »    PDF »
Ras, an Actor on Many Stages: Posttranslational Modifications, Localization, and Site-Specified Events.
I. Arozarena, F. Calvo, and P. Crespo (2011)
Genes & Cancer 2, 182-194
   Abstract »    Full Text »    PDF »
Raf Family Kinases: Old Dogs Have Learned New Tricks.
D. Matallanas, M. Birtwistle, D. Romano, A. Zebisch, J. Rauch, A. von Kriegsheim, and W. Kolch (2011)
Genes & Cancer 2, 232-260
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882