Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 12 October 2010
Vol. 3, Issue 143, p. ra74
[DOI: 10.1126/scisignal.2001077]


Editor's Summary

Gender Bias for Glucocorticoids
The release of glucocorticoids from adrenal glands during times of stress activates transcription of genes encoding factors that suppress inflammation. Synthetic glucocorticoids, such as dexamethasone, are widely prescribed for inflammatory conditions. Because several diseases with inflammatory components show gender-specific differences in prevalence, Duma et al. investigated whether glucocorticoid responses were also gender-biased. Microarray analysis of messenger RNA abundance indicated that dexamethasone treatment of male and female rats increased the number of genes with gender-specific differences in liver expression. In male rat liver, more genes implicated in inflammatory disorders showed dexamethasone-induced alterations (usually decreases) in expression than did genes in female rat liver. In rats injected with lipopolysaccharide (LPS) to trigger systemic inflammation and subsequently treated with dexamethasone, more males than females survived. Male rats produced lower concentrations of inflammatory factors in response to dexamethasone treatment, and ovariectomy improved the survival of female rats after LPS challenge and dexamethasone treatment. The accompanying Perspective by Chrousos discusses the evolutionary context for gender-specific differences in responses to stress, inflammation, and glucocorticoids.

Citation: D. Duma, J. B. Collins, J. W. Chou, J. A. Cidlowski, Sexually Dimorphic Actions of Glucocorticoids Provide a Link to Inflammatory Diseases with Gender Differences in Prevalence. Sci. Signal. 3, ra74 (2010).

Read the Full Text

CDC23 regulates cancer cell phenotype and is overexpressed in papillary thyroid cancer.
L. Zhang, R. Rahbari, M. He, and E. Kebebew (2011)
Endocr. Relat. Cancer 18, 731-742
   Abstract »    Full Text »    PDF »
Stress and Sex Versus Immunity and Inflammation.
G. P. Chrousos (2010)
Science Signaling 3, pe36
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882