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Sci. Signal., 19 October 2010
Vol. 3, Issue 144, p. ra75
[DOI: 10.1126/scisignal.2001275]


Editor's Summary

Keeping Signals Separate
Many signaling pathways involve the same components, yet cells can keep track of multiple inputs and respond with an appropriate output without inappropriately cross-activating pathways that use the same components. Patterson et al. investigated how cells ensure signaling specificity. They used fluorescent reporters and fusion proteins to monitor the response of yeast to two signals, mating pheromone and hyperosmotic stress, which trigger two mitogen-activated protein kinase pathways that share four signaling components. They demonstrated that single cells can respond simultaneously to both pheromone and hyperosmotic stress and, therefore, that each stimulus does not cross-inhibit the other pathway. Their data suggest that inappropriate cross talk is prohibited through a mechanism involving pathway insulation rather than cross-inhibition.

Citation: J. C. Patterson, E. S. Klimenko, J. Thorner, Single-Cell Analysis Reveals That Insulation Maintains Signaling Specificity Between Two Yeast MAPK Pathways with Common Components. Sci. Signal. 3, ra75 (2010).

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Pheromone-Induced Morphogenesis Improves Osmoadaptation Capacity by Activating the HOG MAPK Pathway.
R. Baltanas, A. Bush, A. Couto, L. Durrieu, S. Hohmann, and A. Colman-Lerner (2013)
Science Signaling 6, ra26
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Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems.
G. E. Townsend II, V. Raghavan, I. Zwir, and E. A. Groisman (2013)
PNAS 110, E161-E169
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Expression of Pseudomonas syringae type III effectors in yeast under stress conditions reveals that HopX1 attenuates activation of the high osmolarity glycerol MAP kinase pathway.
D. Salomon, E. Bosis, D. Dar, I. Nachman, and G. Sessa (2012)
Microbiology 158, 2859-2869
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Response to Hyperosmotic Stress.
H. Saito and F. Posas (2012)
Genetics 192, 289-318
   Abstract »    Full Text »    PDF »
The Regulation of Filamentous Growth in Yeast.
P. J. Cullen and G. F. Sprague Jr. (2012)
Genetics 190, 23-49
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Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information.
M. C. Good, J. G. Zalatan, and W. A. Lim (2011)
Science 332, 680-686
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