Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 25 January 2011
Vol. 4, Issue 157, p. ra3
[DOI: 10.1126/scisignal.2001227]

RESEARCH ARTICLES

Editor's Summary

Stopping the Obesity Cycle
Obesity is associated with an increase in lipid storage in adipocytes and a consequent increase in adipocyte size. Changes in cell size affect the cytoskeleton, which is regulated by molecules such as the guanosine triphosphatase Rho and its effector Rho-kinase. Noting that mechanical stretch can lead to activation of the Rho to Rho-kinase (Rho–Rho-kinase) signaling pathway, Hara et al. investigated the role of Rho–Rho-kinase signaling in obesity and its complications. They found that adipocyte Rho-kinase signaling was increased in obese mice fed a high-fat diet. Rho-kinase activity in adipocytes increased with increasing cell size and was also activated by mechanical stretch. Inhibition of Rho-kinase signaling—either systemically or specifically in adipocytes—inhibited the development of an inflammatory obesity-related phenotype in adipose tissue. Moreover, it decreased weight gain in mice fed a high-fat diet and attenuated such pathophysiological complications of obesity as insulin resistance and glucose intolerance. The authors thus propose that adipocyte stretch may contribute to obesity and its complications through activation of Rho–Rho-kinase signaling and that inhibition of this signaling pathway may provide a mechanism for disrupting this cycle.

Citation: Y. Hara, S. Wakino, Y. Tanabe, M. Saito, H. Tokuyama, N. Washida, S. Tatematsu, K. Yoshioka, K. Homma, K. Hasegawa, H. Minakuchi, K. Fujimura, K. Hosoya, K. Hayashi, K. Nakayama, H. Itoh, Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch. Sci. Signal. 4, ra3 (2011).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mevalonate deprivation mediates the impact of lovastatin on the differentiation of murine 3T3-F442A preadipocytes.
M. Elfakhani, S. Torabi, D. Hussein, N. Mills, G. F. Verbeck, and H. Mo (2014)
Experimental Biology and Medicine 239, 293-301
   Abstract »    Full Text »    PDF »
ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance.
S.-H. Lee, H. Huang, K. Choi, D. H. Lee, J. Shi, T. Liu, K. H. Chun, J. A. Seo, I. S. Lima, J. M. Zabolotny, et al. (2014)
Am J Physiol Endocrinol Metab 306, E332-E343
   Abstract »    Full Text »    PDF »
Increased cGMP promotes healthy expansion and browning of white adipose tissue.
M. M. Mitschke, L. S. Hoffmann, T. Gnad, D. Scholz, K. Kruithoff, P. Mayer, B. Haas, A. Sassmann, A. Pfeifer, and A. Kilic (2013)
FASEB J 27, 1621-1630
   Abstract »    Full Text »    PDF »
Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.
S. Mohan, R. Rizaldy, D. Das, R. J. Bauer, A. Heroux, M. A. Trakselis, J. D. Hildebrand, and A. P. VanDemark (2012)
Mol. Biol. Cell 23, 2131-2142
   Abstract »    Full Text »    PDF »
Static mechanical stretching accelerates lipid production in 3T3-L1 adipocytes by activating the MEK signaling pathway.
N. Shoham, R. Gottlieb, O. Sharabani-Yosef, U. Zaretsky, D. Benayahu, and A. Gefen (2012)
Am J Physiol Cell Physiol 302, C429-C441
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 25 January 2011.
S. Wakino, Y. Okada, and A. M. VanHook (2011)
Science Signaling 4, pc2
   Abstract »    Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882