Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 25 January 2011
Vol. 4, Issue 157, p. ra5
[DOI: 10.1126/scisignal.2001279]


Editor's Summary

Acting Locally as Well as Globally
Arginine vasopressin (AVP), which acts as an antidiuretic hormone to decrease plasma osmolarity, is synthesized by osmosensory hypothalamic neurons and released from their terminals in the posterior pituitary into the systemic circulation. Consistent with this homeostatic role, increased plasma osmolarity increases nerve terminal release of AVP, whereas decreased plasma osmolarity decreases it. Here, Sato et al. show that, in contrast to its effect on systemic secretion of AVP, hypo-osmotic stimulation of isolated AVP neurons increased somatodendritic AVP release. AVP acted through the V2 receptor to activate volume-sensitive anion currents and initiate a slow decrease in AVP neuron volume, counteracting the swelling induced by exposure to hypo-osmotic solution. The authors thus conclude that somatodendritic release of AVP acts as an autocrine signal to help AVP neurons maintain an appropriate volume while undergoing hypotonic stress.

Citation: K. Sato, T. Numata, T. Saito, Y. Ueta, Y. Okada, V2 Receptor–Mediated Autocrine Role of Somatodendritic Release of AVP in Rat Vasopressin Neurons Under Hypo-Osmotic Conditions. Sci. Signal. 4, ra5 (2011).

Read the Full Text

DCPIB, the Proposed Selective Blocker of Volume-Regulated Anion Channels, Inhibits Several Glutamate Transport Pathways in Glial Cells.
N. H. Bowens, P. Dohare, Y.-H. Kuo, and A. A. Mongin (2013)
Mol. Pharmacol. 83, 22-32
   Abstract »    Full Text »    PDF »
Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems.
T.-a. Koshimizu, K. Nakamura, N. Egashira, M. Hiroyama, H. Nonoguchi, and A. Tanoue (2012)
Physiol Rev 92, 1813-1864
   Abstract »    Full Text »    PDF »
Epithelial Na+ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei.
R. Teruyama, M. Sakuraba, L. L. Wilson, N. E. J. Wandrey, and W. E. Armstrong (2012)
Am J Physiol Endocrinol Metab 302, E273-E285
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 25 January 2011.
S. Wakino, Y. Okada, and A. M. VanHook (2011)
Science Signaling 4, pc2
   Abstract »    Full Text »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882