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Sci. Signal., 1 February 2011
Vol. 4, Issue 158, p. ra7
[DOI: 10.1126/scisignal.2001147]


Editor's Summary

Antiviral Mitochondrial Action
Mitochondria are the energy generators of the cell, but they also act as platforms upon which complexes of proteins respond to RNA-containing viruses within the cytosol. Through genetic and pharmacological means, Koshiba et al. present evidence that suggests that the contribution of mitochondria to these antiviral responses is not as passive as originally thought. Indeed, their data suggest that successful resistance to viral infections depends on maintenance of the internal physiological functions of mitochondria coupled with the functions of the external protein complexes.

Citation: T. Koshiba, K. Yasukawa, Y. Yanagi, S.-i. Kawabata, Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling. Sci. Signal. 4, ra7 (2011).

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Regulation of Mitochondrial Antiviral Signaling (MAVS) Expression and Signaling by the Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Protein Gp78.
J. L. Jacobs, J. Zhu, S. N. Sarkar, and C. B. Coyne (2014)
J. Biol. Chem. 289, 1604-1616
   Abstract »    Full Text »    PDF »
Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
H. Xu, X. He, H. Zheng, L. J. Huang, F. Hou, Z. Yu, M. J. de la Cruz, B. Borkowski, X. Zhang, Z. J. Chen, et al. (2014)
eLife Sci 3, e01489
   Abstract »    Full Text »    PDF »
Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection.
T. Ichinohe, T. Yamazaki, T. Koshiba, and Y. Yanagi (2013)
PNAS 110, 17963-17968
   Abstract »    Full Text »    PDF »
Mitochondrial morphology transitions and functions: implications for retrograde signaling?.
M. Picard, O. S. Shirihai, B. J. Gentil, and Y. Burelle (2013)
Am J Physiol Regulatory Integrative Comp Physiol 304, R393-R406
   Abstract »    Full Text »    PDF »
5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential.
D. Prantner, D. J. Perkins, W. Lai, M. S. Williams, S. Sharma, K. A. Fitzgerald, and S. N. Vogel (2012)
J. Biol. Chem. 287, 39776-39788
   Abstract »    Full Text »    PDF »
Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential.
Z. T. Varga, A. Grant, B. Manicassamy, and P. Palese (2012)
J. Virol. 86, 8359-8366
   Abstract »    Full Text »    PDF »
Multiple Lines of Evidence Localize Signaling, Morphology, and Lipid Biosynthesis Machinery to the Mitochondrial Outer Membrane of Arabidopsis.
O. Duncan, N. L. Taylor, C. Carrie, H. Eubel, S. Kubiszewski-Jakubiak, B. Zhang, R. Narsai, A. H. Millar, and J. Whelan (2011)
Plant Physiology 157, 1093-1113
   Abstract »    Full Text »    PDF »
Mitochondria in innate immunity.
D. Arnoult, F. Soares, I. Tattoli, and S. E. Girardin (2011)
EMBO Rep. 12, 901-910
   Abstract »    Full Text »    PDF »

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