Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 24 May 2011
Vol. 4, Issue 174, p. ra33
[DOI: 10.1126/scisignal.2001823]


Editor's Summary

Crowd Control for Skin Cells
The adhesion protein α epithelial (αE) catenin has been implicated in limiting epithelial cell proliferation under conditions of high cell density (a process called contact inhibition of cell proliferation). Silvis et al. generated mice lacking αE-catenin in hair follicle stem cells and found that they developed squamous cell carcinomas, thus providing genetic evidence that αE-catenin is a tumor suppressor. The authors identified the transcriptional coactivator Yap1 as a protein that interacted with αE-catenin; this interaction inhibited the activity of Yap1 and prevented Yap1 from translocating to the nucleus. Yap1 is also a target for the Hippo signaling pathway, which restricts cell proliferation and organ size by blocking the nuclear translocation of Yap1. In human squamous cell carcinoma tumors, αE-catenin abundance was inversely correlated with Yap1 activation. Thus, αE-catenin may exert its tumor-suppressive effects by sequestering Yap1 and thereby limiting its activity.

Citation: M. R. Silvis, B. T. Kreger, W.-H. Lien, O. Klezovitch, G. M. Rudakova, F. D. Camargo, D. M. Lantz, J. T. Seykora, V. Vasioukhin, α-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1. Sci. Signal. 4, ra33 (2011).

Read the Full Text

YAP Overexpression Affects Tooth Morphogenesis and Enamel Knot Patterning.
M. Liu, S. Zhao, and X.- P. Wang (2014)
Journal of Dental Research 93, 469-474
   Abstract »    Full Text »    PDF »
{alpha}-Catenin is an inhibitor of transcription.
R. L. Daugherty, L. Serebryannyy, A. Yemelyanov, A. S. Flozak, H.-J. Yu, S. T. Kosak, P. deLanerolle, and C. J. Gottardi (2014)
PNAS 111, 5260-5265
   Abstract »    Full Text »    PDF »
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.
X. Varelas (2014)
Development 141, 1614-1626
   Abstract »    Full Text »    PDF »
Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition.
M. Diepenbruck, L. Waldmeier, R. Ivanek, P. Berninger, P. Arnold, E. van Nimwegen, and G. Christofori (2014)
J. Cell Sci. 127, 1523-1536
   Abstract »    Full Text »    PDF »
The Hippo-YAP signaling pathway and contact inhibition of growth.
B. M. Gumbiner and N.-G. Kim (2014)
J. Cell Sci. 127, 709-717
   Abstract »    Full Text »    PDF »
Responses to Cell Loss Become Restricted as the Supporting Cells in Mammalian Vestibular Organs Grow Thick Junctional Actin Bands That Develop High Stability.
J. C. Burns and J. T. Corwin (2014)
J. Neurosci. 34, 1998-2011
   Abstract »    Full Text »    PDF »
Defining the Protein-Protein Interaction Network of the Human Hippo Pathway.
W. Wang, X. Li, J. Huang, L. Feng, K. G. Dolinta, and J. Chen (2014)
Mol. Cell. Proteomics 13, 119-131
   Abstract »    Full Text »    PDF »
{alpha}-Catenin interacts with APC to regulate {beta}-catenin proteolysis and transcriptional repression of Wnt target genes.
S. H. Choi, C. Estaras, J. J. Moresco, J. R. Yates III, and K. A. Jones (2013)
Genes & Dev. 27, 2473-2488
   Abstract »    Full Text »    PDF »
Hippo Gains Weight: Added Insights and Complexity to Pathway Control.
L. Enderle and H. McNeill (2013)
Science Signaling 6, re7
   Abstract »    Full Text »    PDF »
Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
K. Zhou, A. Muroyama, J. Underwood, R. Leylek, S. Ray, S. H. Soderling, and T. Lechler (2013)
PNAS 110, E3820-E3829
   Abstract »    Full Text »    PDF »
Molecular Pathways: YAP and TAZ Take Center Stage in Organ Growth and Tumorigenesis.
S. Piccolo, M. Cordenonsi, and S. Dupont (2013)
Clin. Cancer Res. 19, 4925-4930
   Abstract »    Full Text »    PDF »
The Hippo pathway: regulators and regulations.
F.-X. Yu and K.-L. Guan (2013)
Genes & Dev. 27, 355-371
   Abstract »    Full Text »    PDF »
Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1.
R. Fan, N.-G. Kim, and B. M. Gumbiner (2013)
PNAS 110, 2569-2574
   Abstract »    Full Text »    PDF »
Intersection of Hippo/YAP and Wnt/{beta}-catenin signaling pathways.
W. M. Konsavage Jr and G. S. Yochum (2013)
Acta Biochim Biophys Sin 45, 71-79
   Abstract »    Full Text »    PDF »
Mechanosensitive systems at the cadherin-F-actin interface.
S. Huveneers and J. de Rooij (2013)
J. Cell Sci. 126, 403-413
   Abstract »    Full Text »    PDF »
The Nuclear Receptor TLX Is Required for Gliomagenesis within the Adult Neurogenic Niche.
Y. Zou, W. Niu, S. Qin, M. Downes, D. K. Burns, and C.-L. Zhang (2012)
Mol. Cell. Biol. 32, 4811-4820
   Abstract »    Full Text »    PDF »
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain.
J. M. Lamar, P. Stern, H. Liu, J. W. Schindler, Z.-G. Jiang, and R. O. Hynes (2012)
PNAS 109, E2441-E2450
   Abstract »    Full Text »    PDF »
Signaling Pathways in Cell Polarity.
L. M. McCaffrey and I. G. Macara (2012)
Cold Spring Harb Perspect Biol 4, a009654
   Abstract »    Full Text »    PDF »
Wnt/{beta}-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells.
W. M. Konsavage Jr., S. L. Kyler, S. A. Rennoll, G. Jin, and G. S. Yochum (2012)
J. Biol. Chem. 287, 11730-11739
   Abstract »    Full Text »    PDF »
Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.
W. Li, J. Cooper, M. A. Karajannis, and F. G. Giancotti (2012)
EMBO Rep. 13, 204-215
   Abstract »    Full Text »    PDF »
Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis.
B. Zhao, L. Li, L. Wang, C.-Y. Wang, J. Yu, and K.-L. Guan (2012)
Genes & Dev. 26, 54-68
   Abstract »    Full Text »    PDF »
Mutational analysis supports a core role for Drosophila {alpha}-Catenin in adherens junction function.
R. Sarpal, M. Pellikka, R. R. Patel, F. Y. W. Hui, D. Godt, and U. Tepass (2012)
J. Cell Sci. 125, 233-245
   Abstract »    Full Text »    PDF »
The secret life of {alpha}-catenin: Moonlighting in morphogenesis.
S. L. Maiden and J. Hardin (2011)
J. Cell Biol. 195, 543-552
   Abstract »    Full Text »    PDF »
Hippo pathway regulation by cell morphology and stress fibers.
K.-I. Wada, K. Itoga, T. Okano, S. Yonemura, and H. Sasaki (2011)
Development 138, 3907-3914
   Abstract »    Full Text »    PDF »
Stem Cell Proliferation in the Skin: {alpha}-Catenin Takes Over the Hippo Pathway.
E. R. Flores and G. Halder (2011)
Science Signaling 4, pe34
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 24 May 2011.
J. F. Martin, V. Vasioukhin, M. R. Silvis, and A. M. VanHook (2011)
Science Signaling 4, pc10
   Abstract »    Full Text »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882