Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 31 May 2011
Vol. 4, Issue 175, p. ra36
Natural killer (NK) cell activity depends on the interplay between activating and inhibitory receptors. Activating receptors stimulate the recruitment and phosphorylation of Vav1, a factor required to drive formation of the contact area between the NK cell and its target. Conversely, inhibitory receptor signaling results in the dephosphorylation of Vav1 to block activation. Mesecke et al. modeled multiple combinations of signaling events upstream of Vav1, classifying the input-output behaviors into different phenotypic classes. The authors used their models to predict that Vav1 occupied a central "decision-making" hub in the crosstalk between activating and inhibitory signals and that the phosphorylation of Vav1 depended on the physical association of activating receptors with Src family kinases. Further, the extent of phosphorylation of Vav1 correlated with the cytotoxic activity of NK cells. Validation of these predictions in NK cells suggests that this mathematical approach may prove useful in understanding the nonlinear integration of opposing signals in other systems.
Citation: S. Mesecke, D. Urlaub, H. Busch, R. Eils, C. Watzl, Integration of Activating and Inhibitory Receptor Signaling by Regulated Phosphorylation of Vav1 in Immune Cells. Sci. Signal.4, ra36 (2011).
Kristen L. Mueller (24 January 2012) Sci. Signal.5 (208), ec32.
[DOI: 10.1126/scisignal.2002876] |Abstract »
Leo M. Carlin, Rachel Evans, Hanna Milewicz, Luis Fernandes, Daniel R. Matthews, Michela Perani, James Levitt, Melanie D. Keppler, James Monypenny, Ton Coolen, Paul R. Barber, Borivoj Vojnovic, Klaus Suhling, Franca Fraternali, Simon Ameer-Beg, Peter J. Parker, N. Shaun B. Thomas, and Tony Ng (29 November 2011) Sci. Signal.4 (201), ra81.
[DOI: 10.1126/scisignal.2001729] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Sophie Guia, Baptiste N. Jaeger, Stefan Piatek, Sébastien Mailfert, Tomasz Trombik, Aurore Fenis, Nicolas Chevrier, Thierry Walzer, Yann M. Kerdiles, Didier Marguet, Eric Vivier, and Sophie Ugolini (5 April 2011) Sci. Signal.4 (167), ra21.
[DOI: 10.1126/scisignal.2001608] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Alexander Saveliev, Lesley Vanes, Olga Ksionda, Jonathan Rapley, Stephen J. Smerdon, Katrin Rittinger, and Victor L. J. Tybulewicz (15 December 2009) Sci. Signal.2 (101), ra83.
[DOI: 10.1126/scisignal.2000420] |Editor's Summary »|Abstract »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins.
A. C. N. Brown, I. M. Dobbie, J.-M. Alakoskela, I. Davis, and D. M. Davis (2012)
|Abstract »|Full Text »|PDF »
Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration.