Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 14 June 2011
Vol. 4, Issue 177, p. ra41
[DOI: 10.1126/scisignal.2001538]


Editor's Summary

Parsing Breast Cancer Subtype with MicroRNAs
MicroRNAs (miRNAs), short noncoding RNAs that bind to and silence target mRNAs, have emerged as playing crucial regulatory roles not only in normal cellular processes but also in pathological conditions, such as cancer. Stinson et al. analyzed miRNA expression in different types of human breast cancer and found that miR-221 and miR-222 (miR-221/222) abundance was increased in the clinically aggressive basal-like subtype compared to the less aggressive luminal subtype. They determined that signaling through the epidermal growth factor receptor (EGFR)–RAS–extracellular signal–regulated kinase (ERK) pathway increased miR-221/222 transcription, and they defined a transcriptional regulatory pathway through which miR-221/222 promoted a phenotype associated with cancer cell invasion and metastasis. Their data suggest that combining inhibition of the EGFR-RAS-ERK pathway with standard chemotherapy could, by limiting miR-221/222 production, provide a strategy to combat metastasis in the basal-like subtype of breast cancer.

Citation: S. Stinson, M. R. Lackner, A. T. Adai, N. Yu, H.-J. Kim, C. O’Brien, J. Spoerke, S. Jhunjhunwala, Z. Boyd, T. Januario, R. J. Newman, P. Yue, R. Bourgon, Z. Modrusan, H. M. Stern, S. Warming, F. J. de Sauvage, L. Amler, R.-F. Yeh, D. Dornan, TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer. Sci. Signal. 4, ra41 (2011).

Read the Full Text

TRPS1 expression promotes angiogenesis and affects VEGFA expression in breast cancer.
J. Hu, P. Su, M. Jia, X. Wu, H. Zhang, W. Li, and G. Zhou (2014)
Experimental Biology and Medicine 239, 423-429
   Abstract »    Full Text »    PDF »
Post-transcriptional Regulation of Human Breast Cancer Cell Proteome by Unliganded Estrogen Receptor {beta} via microRNAs.
G. Nassa, R. Tarallo, G. Giurato, M. R. De Filippo, M. Ravo, F. Rizzo, C. Stellato, C. Ambrosino, M. Baumann, N. Lietzen, et al. (2014)
Mol. Cell. Proteomics 13, 1076-1090
   Abstract »    Full Text »    PDF »
Decreased miR-340 Expression in Bone Marrow Is Associated with Liver Metastasis of Colorectal Cancer.
H. Takeyama, H. Yamamoto, S. Yamashita, X. Wu, H. Takahashi, J. Nishimura, N. Haraguchi, Y. Miyake, R. Suzuki, K. Murata, et al. (2014)
Mol. Cancer Ther. 13, 976-985
   Abstract »    Full Text »    PDF »
Prognostic value of the trichorhinophalangeal syndrome-1 (TRPS-1), a GATA family transcription factor, in early-stage breast cancer.
J. Q. Chen, Y. Bao, J. Lee, J. L. Murray, J. K. Litton, L. Xiao, R. Zhou, Y. Wu, X. Y. Shen, H. Zhang, et al. (2013)
Ann. Onc. 24, 2534-2542
   Abstract »    Full Text »    PDF »
Pathogenic arterial remodeling: the good and bad of microRNAs.
Y. Wei, A. Schober, and C. Weber (2013)
Am J Physiol Heart Circ Physiol 304, H1050-H1059
   Abstract »    Full Text »    PDF »
Epithelial-mesenchymal transitions: insights from development.
J. Lim and J. P. Thiery (2012)
Development 139, 3471-3486
   Abstract »    Full Text »    PDF »
ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors.
G. Hatzivassiliou, B. Liu, C. O'Brien, J. M. Spoerke, K. P. Hoeflich, P. M. Haverty, R. Soriano, W. F. Forrest, S. Heldens, H. Chen, et al. (2012)
Mol. Cancer Ther. 11, 1143-1154
   Abstract »    Full Text »    PDF »
DNA Methylation Profiling Defines Clinically Relevant Biological Subsets of Non-Small Cell Lung Cancer.
K. Walter, T. Holcomb, T. Januario, P. Du, M. Evangelista, N. Kartha, L. Iniguez, R. Soriano, L. Huw, H. Stern, et al. (2012)
Clin. Cancer Res. 18, 2360-2373
   Abstract »    Full Text »    PDF »
Serum microRNA profiling and breast cancer risk: the use of miR-484/191 as endogenous controls.
Z. Hu, J. Dong, L.-E. Wang, H. Ma, J. Liu, Y. Zhao, J. Tang, X. Chen, J. Dai, Q. Wei, et al. (2012)
Carcinogenesis 33, 828-834
   Abstract »    Full Text »    PDF »
Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA.
S. Volinia, M. Galasso, M. E. Sana, T. F. Wise, J. Palatini, K. Huebner, and C. M. Croce (2012)
PNAS 109, 3024-3029
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882