Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Signal., 26 July 2011
Vol. 4, Issue 183, p. ra48
[DOI: 10.1126/scisignal.2001902]

RESEARCH ARTICLES

Editor's Summary

Age of the Acetylome
Acetylation and phosphorylation are regulatory posttranslational modifications that occur on proteins. With proteome-wide data in divergent species, insights regarding the evolution of these two regulatory processes can be revealed. Weinert et al. report the proteome-wide analysis of acetylated proteins in the fruit fly. Comparing the data on acetylated proteins in humans and flies with proteome sequences of nematodes and zebrafish indicated that acetylated sites were more conserved than were nonacetylated sites, and comparison of the human and fly acetylomes with their phosphoproteomes indicated that acetylation sites were more conserved than were phosphorylation sites. Acetylation intersected with another posttranslational modification, ubiquitylation: Acetylation occurred on one-third of human ubiquitin-conjugating E2 enzymes and influenced the activity of these enzymes, suggesting that acetylation provides another regulatory layer for this other type of posttranslational modification.

Citation: B. T. Weinert, S. A. Wagner, H. Horn, P. Henriksen, W. R. Liu, J. V. Olsen, L. J. Jensen, C. Choudhary, Proteome-Wide Mapping of the Drosophila Acetylome Demonstrates a High Degree of Conservation of Lysine Acetylation. Sci. Signal. 4, ra48 (2011).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
L. Mitchell, S. Huard, M. Cotrut, R. Pourhanifeh-Lemeri, A.-L. Steunou, A. Hamza, J.-P. Lambert, H. Zhou, Z. Ning, A. Basu, et al. (2013)
PNAS 110, E1641-E1650
   Abstract »    Full Text »    PDF »
Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease.
J. C. Newman, W. He, and E. Verdin (2012)
J. Biol. Chem. 287, 42436-42443
   Abstract »    Full Text »    PDF »
Mechanistic insights into the regulation of metabolic enzymes by acetylation.
Y. Xiong and K.-L. Guan (2012)
J. Cell Biol. 198, 155-164
   Abstract »    Full Text »    PDF »
Lysine Acetylation Is Widespread on Proteins of Diverse Function and Localization in the Protozoan Parasite Toxoplasma gondii.
V. Jeffers and W. J. Sullivan Jr. (2012)
Eukaryot. Cell 11, 735-742
   Abstract »    Full Text »    PDF »
Computational Approaches for Analyzing Information Flow in Biological Networks.
B. Kholodenko, M. B. Yaffe, and W. Kolch (2012)
Science Signaling 5, re1
   Abstract »    Full Text »    PDF »
Database independent proteomics analysis of the ostrich and human proteome.
A. F. M. Altelaar, D. Navarro, J. Boekhorst, B. van Breukelen, B. Snel, S. Mohammed, and A. J. R. Heck (2012)
PNAS 109, 407-412
   Abstract »    Full Text »    PDF »
Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK.
Y. Xiong, Q.-Y. Lei, S. Zhao, and K.-L. Guan (2011)
Cold Spring Harb Symp Quant Biol 76, 285-289
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882