Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 23 August 2011
Vol. 4, Issue 187, p. ra55
[DOI: 10.1126/scisignal.2002006]

RESEARCH ARTICLES

Editor's Summary

Defining a Migratory Route
The serine-threonine kinase Tpl2, a mitogen-activated protein kinase kinase kinase, transduces signals from various plasma membrane receptors and has been implicated in pathways contributing to cancer and inflammation. Building on their earlier work showing that Tpl2 promotes cell migration in response to thrombin activation of the G protein–coupled receptor (GPCR) PAR1, Hatziapostolou et al. now define the signaling pathways through which this occurs. They found that PAR1 coupled to Gαi2 to activate Tpl2 and implicated the subsequent activation of phospholipase C–β3, production of inositol 1,4,5-trisphosphate, and cytoplasmic calcium signals in the migratory response. Moreover, they showed that Tpl2 mediated migratory signals through activation of several receptors other than PAR1. Their data contribute to our understanding of the pathways through which GPCRs and other receptors promote cell migration and may be pertinent to the mechanisms whereby Tpl2 contributes to cancer and inflammation.

Citation: M. Hatziapostolou, G. Koukos, C. Polytarchou, F. Kottakis, O. Serebrennikova, A. Kuliopulos, P. N. Tsichlis, Tumor Progression Locus 2 Mediates Signal-Induced Increases in Cytoplasmic Calcium and Cell Migration. Sci. Signal. 4, ra55 (2011).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasis.
K. L. DeCicco-Skinner, S. A. Jung, T. Tabib, J. C. Gwilliam, H. Alexander, S. E. Goodheart, A. S. Merchant, M. Shan, C. Garber, and J. S. Wiest (2013)
Carcinogenesis 34, 2789-2798
   Abstract »    Full Text »    PDF »
Tpl2 Kinase Impacts Tumor Growth and Metastasis of Clear Cell Renal Cell Carcinoma.
H. W. Lee, K. M. Joo, J. E. Lim, H. J. Cho, H. J. Cho, M. C. Park, H. J. Seol, S. I. Seo, J.-I. Lee, S. Kim, et al. (2013)
Mol. Cancer Res. 11, 1375-1386
   Abstract »    Full Text »    PDF »
Tpl2 kinase regulates Fc{gamma}R signaling and immune thrombocytopenia in mice.
I. Kyrmizi, M. Ioannou, M. Hatziapostolou, P. N. Tsichlis, D. T. Boumpas, and I. Tassiulas (2013)
J. Leukoc. Biol. 94, 751-757
   Abstract »    Full Text »    PDF »
Noncanonical Matrix Metalloprotease-1-Protease-activated Receptor-1 Signaling Triggers Vascular Smooth Muscle Cell Dedifferentiation and Arterial Stenosis.
K. M. Austin, N. Nguyen, G. Javid, L. Covic, and A. Kuliopulos (2013)
J. Biol. Chem. 288, 23105-23115
   Abstract »    Full Text »    PDF »
Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages.
M. Lopez-Pelaez, S. Fumagalli, C. Sanz, C. Herrero, S. Guerra, M. Fernandez, and S. Alemany (2012)
Mol. Biol. Cell 23, 2982-2992
   Abstract »    Full Text »    PDF »
Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.
O. B. Serebrennikova, C. Tsatsanis, C. Mao, E. Gounaris, W. Ren, L. D. Siracusa, A. G. Eliopoulos, K. Khazaie, and P. N. Tsichlis (2012)
PNAS 109, E1082-E1091
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882