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Sci. Signal., 27 September 2011
Vol. 4, Issue 192, p. ra64
[DOI: 10.1126/scisignal.2002049]

RESEARCH ARTICLES

Editor's Summary

GIVing Migration a Boost
Phosphoinositide 3-kinase (PI3K) can promote cell migration, and the activation of PI3K occurs downstream of ligand binding to several cell surface receptors. Lin et al. show that the guanine nucleotide exchange factor GIV (Gα-interacting vesicle-associated protein) may link ligand stimulation of these receptors to activation of PI3K. GIV was tyrosine phosphorylated by various receptor and non-receptor tyrosine kinases, and these phosphorylation events enabled GIV to bind to a regulatory subunit of PI3K, increase PI3K activity at the plasma membrane, and promote cell migration. The metastatic and invasive extent of a breast carcinoma was positively correlated to tyrosine phosphorylation of GIV and its association with the regulatory subunit of PI3K. Thus, manipulations that prevent or decrease the tyrosine phosphorylation of GIV could potentially be used to slow the progression of invasive cancers.

Citation: C. Lin, J. Ear, Y. Pavlova, Y. Mittal, I. Kufareva, M. Ghassemian, R. Abagyan, M. Garcia-Marcos, P. Ghosh, Tyrosine Phosphorylation of the Gα-Interacting Protein GIV Promotes Activation of Phosphoinositide 3-Kinase During Cell Migration. Sci. Signal. 4, ra64 (2011).

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