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Sci. Signal., 11 October 2011
Vol. 4, Issue 194, p. ra68
Mad for Both Wingless and BMP
The Wingless (also known as Wnt) and bone morphogenetic protein (BMP) signaling pathways are critical during development. In the Drosophila BMP signaling pathway, ligand-bound BMP receptors phosphorylate sites in the C terminus of the transcription factor Mad, thereby activating it. The BMP signal is terminated by degradation of Mad, a process that requires phosphorylation of Mad at sites distinct from those that activate it. Eivers et al. now show a role for unphosphorylated Mad in Wingless signaling. Drosophila with a mutant form of Mad with reduced degradation showed developmental defects typical of excess Wingless signaling, and phosphorylation-resistant Mad interacted with two transcriptional effectors of the Wingless pathway. Thus, the phosphorylation state of Mad determines whether it participates in BMP or Wingless signaling.
Citation: E. Eivers, H. Demagny, R. H. Choi, E. M. De Robertis, Phosphorylation of Mad Controls Competition Between Wingless and BMP Signaling. Sci. Signal.4, ra68 (2011).