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Sci. Signal., 25 October 2011
Vol. 4, Issue 196, p. rs10
[DOI: 10.1126/scisignal.2002029]


Editor's Summary

Finding the Shared and the Specific Components Regulating MAPK Signals
Even in extensively studied pathways, such as the extracellular signal–regulated kinase (ERK) pathway that is activated by receptor tyrosine kinases, there remain gaps in our knowledge. Friedman et al. combined protein-protein interaction screens with RNAi functional genomic screens in Drosophila cell lines to identify components of the ERK pathway downstream of two receptor tyrosine kinases. Their analysis suggested that these receptors may compete for some common components, in addition to using receptor-specific and cell-specific signal transduction pathways. Knockdown of several newly identified pathway regulators resulted in wing phenotypes in vivo, confirming these as components in the pathway. Detailed understanding of this pathway has clinical relevance because of its importance in both physiological and pathophysiological contexts, such as cell fate decisions and mechanisms of oncogenesis and resistance to chemotherapy.

Citation: A. A. Friedman, G. Tucker, R. Singh, D. Yan, A. Vinayagam, Y. Hu, R. Binari, P. Hong, X. Sun, M. Porto, S. Pacifico, T. Murali, R. L. Finley, Jr., J. M. Asara, B. Berger, N. Perrimon, Proteomic and Functional Genomic Landscape of Receptor Tyrosine Kinase and Ras to Extracellular Signal–Regulated Kinase Signaling. Sci. Signal. 4, rs10 (2011).

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Visualizing and Manipulating Temporal Signaling Dynamics with Fluorescence-Based Tools.
D. P. Doupe and N. Perrimon (2014)
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The Hippo Signaling Pathway Interactome.
Y. Kwon, A. Vinayagam, X. Sun, N. Dephoure, S. P. Gygi, P. Hong, and N. Perrimon (2013)
Science 342, 737-740
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Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
K. M. Brown, J. P. Day, E. Huston, B. Zimmermann, K. Hampel, F. Christian, D. Romano, S. Terhzaz, L. C. Y. Lee, M. J. Willis, et al. (2013)
PNAS 110, E1533-E1542
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Protein Complex-Based Analysis Framework for High-Throughput Data Sets.
A. Vinayagam, Y. Hu, M. Kulkarni, C. Roesel, R. Sopko, S. E. Mohr, and N. Perrimon (2013)
Science Signaling 6, rs5
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Detection of a rare BCR-ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS).
S. B. Breitkopf, M. Yuan, G. A. Pihan, and J. M. Asara (2012)
PNAS 109, 16190-16195
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Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens.
V. A. Meliopoulos, L. E. Andersen, K. F. Birrer, K. J. Simpson, J. W. Lowenthal, A. G. D. Bean, J. Stambas, C. R. Stewart, S. M. Tompkins, V. W. van Beusechem, et al. (2012)
FASEB J 26, 1372-1386
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 25 October 2011.
A. A. Friedman, N. Perrimon, and A. M. VanHook (2011)
Science Signaling 4, pc22
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