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Sci. Signal., 1 November 2011 RESEARCH ARTICLESEditor's Summary Limiting Persistent InflammationInterleukin-17 (IL-17) is a proinflammatory cytokine that is required for immune responses to extracellular pathogens, but it is also implicated in autoimmune disorders and inflammatory diseases. Signaling through the IL-17 receptor (IL-17R) requires the adaptor protein Act1 and leads to activation of the transcription factor NF- B. Shi et al. found that persistent stimulation of HeLa cells with IL-17 led to a loss of Act1 protein and inhibited responses of the cells to subsequent exposure to the cytokine. Stimulation with IL-17 led to phosphorylation, ubiquitination, and proteasomal degradation of Act1. The authors identified SCFβ-TrCP as the E3 ubiquitin ligase complex responsible for Act1 ubiquitination. SCFβ-TrCP is also required for IL-17–dependent degradation of the inhibitor of B (IB) protein to enable NF-B activation, positioning SCFβ-TrCP as both a positive and a negative regulator of IL-17 signaling.
Citation: P. Shi, S. Zhu, Y. Lin, Y. Liu, Y. Liu, Z. Chen, Y. Shi, Y. Qian, Persistent Stimulation with Interleukin-17 Desensitizes Cells Through SCFβ-TrCP-Mediated Degradation of Act1. Sci. Signal. 4, ra73 (2011). The editors suggest the following Related Resources on Science sites:In Science Signaling
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882
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