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Sci. Signal., 15 November 2011
Vol. 4, Issue 199, p. ra75
Components of the extracellular matrix have structural roles, but various stresses can induce the release of soluble fragments of these components that can participate in signaling pathways. Merline et al. showed that the soluble form of the proteoglycan decorin promoted inflammatory activity by attenuating the release of anti-inflammatory factors and by activating receptors that trigger the production of proinflammatory mediators. Septic patients showed increased plasma concentrations of decorin, and mice lacking decorin showed increased production of anti-inflammatory factors and decreased production of proinflammatory factors during sepsis. Injecting established tumors in mice with an adenovirus expressing decorin resulted in reduced tumor growth. Thus, treatments that decrease decorin abundance could be used to calm inflammation during sepsis, whereas those that increase decorin abundance might be of clinical use in reducing tumor growth.
Citation: R. Merline, K. Moreth, J. Beckmann, M. V. Nastase, J. Zeng-Brouwers, J. G. Tralhão, P. Lemarchand, J. Pfeilschifter, R. M. Schaefer, R. V. Iozzo, L. Schaefer, Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21. Sci. Signal.4, ra75 (2011).
Yuanzheng He, Yong Xu, Chenghai Zhang, Xiang Gao, Karl J. Dykema, Katie R. Martin, Jiyuan Ke, Eric A. Hudson, Sok Kean Khoo, James H. Resau, Arthur S. Alberts, Jeffrey P. MacKeigan, Kyle A. Furge, and H. Eric Xu (5 July 2011) Sci. Signal.4 (180), ra44.
[DOI: 10.1126/scisignal.2001450] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression.
M. Blich, A. Golan, G. Arvatz, A. Sebbag, I. Shafat, E. Sabo, V. Cohen-Kaplan, S. Petcherski, S. Avniel-Polak, A. Eitan, et al. (2013)
Arterioscler Thromb Vasc Biol
|Abstract »|Full Text »|PDF »
An Introduction to Proteoglycans and Their Localization.