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Sci. Signal., 15 November 2011
Vol. 4, Issue 199, p. ra77
Programming T Cell Survival
The development of thymocytes in the thymus critically depends on signals through the T cell antigen receptor (TCR) and the receptor for the homeostatic cytokine interleukin-7 (IL-7). During development, thymocytes lose IL-7Rα but regain the receptor after they receive signals through the TCR in a process known as positive selection. When thymocytes leave the thymus as mature T lymphocytes and move to peripheral lymphoid organs, they still depend on TCR and IL-7R signaling for their survival. Sinclair et al. found that TCR signaling in developing thymocytes in the mouse activated the reexpression of Il7r and the reappearance of IL-7Rα on the cell surface. The abundance of surface IL-7Rα correlated with the strength of positive selection, and those T cells with the highest abundance of IL-7Rα had the greatest chance of survival in the periphery. In contrast, TCR signaling in peripheral T cells did not alter the abundance or function of IL-7Rα. Together, these data suggest that TCR-dependent regulation of IL-7Rα abundance on thymocytes determines the long-term survivability of the resulting T cells.
Citation: C. Sinclair, M. Saini, I. Schim van der Loeff, S. Sakaguchi, B. Seddon, The Long-Term Survival Potential of Mature T Lymphocytes Is Programmed During Development in the Thymus. Sci. Signal.4, ra77 (2011).
CD8 Lineage-specific Regulation of Interleukin-7 Receptor Expression by the Transcriptional Repressor Gfi1.
D. L. Ligons, C. Tuncer, B. A. Linowes, I. M. Akcay, S. Kurtulus, E. Deniz, B. Atasever Arslan, S. I. Cevik, H. R. Keller, M. A. Luckey, et al. (2012)
J. Biol. Chem.
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