Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 29 November 2011
Vol. 4, Issue 201, p. ra80
Preventing Muscle Wasting
The wasting of skeletal muscle that accompanies various diseases (such as cancer, AIDS, and COPD) contributes to a poor prognosis. Thus, identifying pathways that promote muscle growth and can counteract muscle wasting can reduce the morbidity and mortality associated with these diseases. Minetti et al. (see also the Perspective by Guttridge) show that signaling through the G protein Gαi2 can increase growth and differentiation of muscle cells, promote regeneration after injury in mice, and counteract atrophy in vitro.
Citation: G. C. Minetti, J. N. Feige, A. Rosenstiel, F. Bombard, V. Meier, A. Werner, F. Bassilana, A. W. Sailer, P. Kahle, C. Lambert, D. J. Glass, M. Fornaro, Gαi2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration. Sci. Signal.4, ra80 (2011).
The editors suggest the following Related Resources on Science sites:
In Science Signaling
Huibin Tang, Ken Inoki, Myung Lee, Erika Wright, Andy Khuong, Amanda Khuong, Sista Sugiarto, Matthew Garner, Jihye Paik, Ronald A. DePinho, Daniel Goldman, Kun-Liang Guan, and Joseph B. Shrager (25 February 2014) Sci. Signal.7 (314), ra18.
[DOI: 10.1126/scisignal.2004809] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
Leslie K. Ferrarelli (20 August 2013) Sci. Signal.6 (289), ec192.
[DOI: 10.1126/scisignal.2004642] |Abstract »
Leslie K. Ferrarelli (1 January 2013) Sci. Signal.6 (256), ec1.
[DOI: 10.1126/scisignal.2003914] |Abstract »