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Sci. Signal., 29 November 2011
Vol. 4, Issue 201, p. ra80
[DOI: 10.1126/scisignal.2002038]


Editor's Summary

Preventing Muscle Wasting
The wasting of skeletal muscle that accompanies various diseases (such as cancer, AIDS, and COPD) contributes to a poor prognosis. Thus, identifying pathways that promote muscle growth and can counteract muscle wasting can reduce the morbidity and mortality associated with these diseases. Minetti et al. (see also the Perspective by Guttridge) show that signaling through the G protein Gαi2 can increase growth and differentiation of muscle cells, promote regeneration after injury in mice, and counteract atrophy in vitro.

Citation: G. C. Minetti, J. N. Feige, A. Rosenstiel, F. Bombard, V. Meier, A. Werner, F. Bassilana, A. W. Sailer, P. Kahle, C. Lambert, D. J. Glass, M. Fornaro, Gαi2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration. Sci. Signal. 4, ra80 (2011).

Read the Full Text

G{alpha}i2 Signaling Is Required for Skeletal Muscle Growth, Regeneration, and Satellite Cell Proliferation and Differentiation.
G. C. Minetti, J. N. Feige, F. Bombard, A. Heier, F. Morvan, B. Nurnberg, V. Leiss, L. Birnbaumer, D. J. Glass, and M. Fornaro (2014)
Mol. Cell. Biol. 34, 619-630
   Abstract »    Full Text »    PDF »
Cellular and molecular mechanisms of muscle atrophy.
P. Bonaldo and M. Sandri (2013)
Dis. Model. Mech. 6, 25-39
   Abstract »    Full Text »    PDF »
cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration.
R. Berdeaux and R. Stewart (2012)
Am J Physiol Endocrinol Metab 303, E1-E17
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 27 March 2012.
D. J. Glass and A. M. VanHook (2012)
Science Signaling 5, pc6
   Abstract »    Full Text »
Making Muscles Grow by G Protein-Coupled Receptor Signaling.
D. C. Guttridge (2011)
Science Signaling 4, pe45
   Abstract »    Full Text »    PDF »

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