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Sci. Signal., 6 December 2011
Vol. 4, Issue 202, p. ra84
[DOI: 10.1126/scisignal.2002058]


Editor's Summary

PKC Isoform Specificity in T Cells
When a T cell encounters an antigen-presenting cell (APC), protein kinase C {theta} (PKC{theta}) is recruited to the immunological synapse, the interface between the T cell and the APC, where it is thought to mediate co-receptor signaling during T cell activation. Although PKC{theta} is the most abundant PKC isoform in T cells, thymocyte development in PKC{theta}-deficient mice is only mildly affected. Fu et al. investigated a role for PKC{eta}, which, unlike PKC{theta}, increases in abundance upon T cell activation. The authors found that similar to PKC{theta}, PKC{eta} was recruited to the immunological synapse upon T cell activation and that both isoforms had some overlapping functions. However, PKC{eta} was required for antigen-dependent activation, and loss of PKC{eta}, but not that of PKC{theta}, resulted in decreased homeostatic proliferation of T cells. Together, these data suggest that PKC{eta} plays critical roles in T cells.

Citation: G. Fu, J. Hu, N. Niederberger-Magnenat, V. Rybakin, J. Casas, P. P. Yachi, S. Feldstein, B. Ma, J. A. H. Hoerter, J. Ampudia, S. Rigaud, F. Lambolez, A. L. Gavin, K. Sauer, H. Cheroutre, N. R. J. Gascoigne, Protein Kinase C {eta} Is Required for T Cell Activation and Homeostatic Proliferation. Sci. Signal. 4, ra84 (2011).

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