Sci. Signal., 6 December 2011
PKC Isoform Specificity in T CellsWhen a T cell encounters an antigen-presenting cell (APC), protein kinase C (PKC) is recruited to the immunological synapse, the interface between the T cell and the APC, where it is thought to mediate co-receptor signaling during T cell activation. Although PKC is the most abundant PKC isoform in T cells, thymocyte development in PKC-deficient mice is only mildly affected. Fu et al. investigated a role for PKC, which, unlike PKC, increases in abundance upon T cell activation. The authors found that similar to PKC, PKC was recruited to the immunological synapse upon T cell activation and that both isoforms had some overlapping functions. However, PKC was required for antigen-dependent activation, and loss of PKC, but not that of PKC, resulted in decreased homeostatic proliferation of T cells. Together, these data suggest that PKC plays critical roles in T cells.
Citation: G. Fu, J. Hu, N. Niederberger-Magnenat, V. Rybakin, J. Casas, P. P. Yachi, S. Feldstein, B. Ma, J. A. H. Hoerter, J. Ampudia, S. Rigaud, F. Lambolez, A. L. Gavin, K. Sauer, H. Cheroutre, N. R. J. Gascoigne, Protein Kinase C Is Required for T Cell Activation and Homeostatic Proliferation. Sci. Signal. 4, ra84 (2011).
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