Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 6 December 2011
Vol. 4, Issue 202, p. ra84
[DOI: 10.1126/scisignal.2002058]

RESEARCH ARTICLES

Editor's Summary

PKC Isoform Specificity in T Cells
When a T cell encounters an antigen-presenting cell (APC), protein kinase C {theta} (PKC{theta}) is recruited to the immunological synapse, the interface between the T cell and the APC, where it is thought to mediate co-receptor signaling during T cell activation. Although PKC{theta} is the most abundant PKC isoform in T cells, thymocyte development in PKC{theta}-deficient mice is only mildly affected. Fu et al. investigated a role for PKC{eta}, which, unlike PKC{theta}, increases in abundance upon T cell activation. The authors found that similar to PKC{theta}, PKC{eta} was recruited to the immunological synapse upon T cell activation and that both isoforms had some overlapping functions. However, PKC{eta} was required for antigen-dependent activation, and loss of PKC{eta}, but not that of PKC{theta}, resulted in decreased homeostatic proliferation of T cells. Together, these data suggest that PKC{eta} plays critical roles in T cells.

Citation: G. Fu, J. Hu, N. Niederberger-Magnenat, V. Rybakin, J. Casas, P. P. Yachi, S. Feldstein, B. Ma, J. A. H. Hoerter, J. Ampudia, S. Rigaud, F. Lambolez, A. L. Gavin, K. Sauer, H. Cheroutre, N. R. J. Gascoigne, Protein Kinase C {eta} Is Required for T Cell Activation and Homeostatic Proliferation. Sci. Signal. 4, ra84 (2011).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882