Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 13 December 2011
Vol. 4, Issue 203, p. ra87
[DOI: 10.1126/scisignal.2002033]

RESEARCH ARTICLES

Editor's Summary

Acting Together Rather than in Isolation
Members of the phosphoinositide family of membrane lipids mediate numerous cellular functions, leading to the question of how a limited set of signaling molecules can give rise to a wide spectrum of effects. Ueno et al. used two different techniques to rapidly manipulate the local concentration of the second messenger phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], only one of which was accompanied by a decrease in the concentration of its precursor, phosphatidylinositol 4-phosphate [PI(4)P]. Intriguingly, they found that the effect on the actin cytoskeleton of the combination of an increase in PI(4,5)P2 and a decrease in PI(4)P was entirely distinct from that of increasing PI(4,5)P2 without decreasing PI(4)P. Thus, the authors concluded that combinatorial regulation of the concentrations of distinct but closely related membrane phosphoinositides may at least partly explain the ability of this family of signaling molecules to produce such functionally diverse responses.

Citation: T. Ueno, B. H. Falkenburger, C. Pohlmeyer, T. Inoue, Triggering Actin Comets Versus Membrane Ruffles: Distinctive Effects of Phosphoinositides on Actin Reorganization. Sci. Signal. 4, ra87 (2011).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Signaling inputs to invadopodia and podosomes.
D. Hoshino, K. M. Branch, and A. M. Weaver (2013)
J. Cell Sci. 126, 2979-2989
   Abstract »    Full Text »    PDF »
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation.
T. Balla (2013)
Physiol Rev 93, 1019-1137
   Abstract »    Full Text »    PDF »
Quantitative properties and receptor reserve of the DAG and PKC branch of Gq-coupled receptor signaling.
B. H. Falkenburger, E. J. Dickson, and B. Hille (2013)
J. Gen. Physiol. 141, 537-555
   Abstract »    Full Text »    PDF »
How Actin Gets the PIP.
S. E. Moss (2012)
Science Signaling 5, pe7
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882