Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Signal., 10 January 2012
Vol. 5, Issue 206, p. ra4
[DOI: 10.1126/scisignal.2002414]

RESEARCH ARTICLES

Editor's Summary

A Toothsome Circuit
Interactions between two different types of tissue, epithelium and mesenchyme, play important roles in development and cancer. Tooth development is a system for studying epithelial-mesenchymal interactions that is amenable to experimental manipulation. O’Connell et al. performed gene expression profiling of developing molar dental tissues in mice and computational analyses to construct a gene regulatory network that identified a key feedback circuit mediated by diffusible signaling molecules of the Wnt and Bmp families. This circuit controls the production of signaling molecules in other pathways and is self-sustaining. The authors validated their circuit in mice with mutations expected to disrupt the Wnt-Bmp signaling pathways. Similar feedback circuits may also operate in epithelial-mesenchymal interactions in other developing organs or in tumors.

Citation: D. J. O’Connell, J. W. K. Ho, T. Mammoto, A. Turbe-Doan, J. T. O’Connell, P. S. Haseley, S. Koo, N. Kamiya, D. E. Ingber, P. J. Park, R. L. Maas, A Wnt-Bmp Feedback Circuit Controls Intertissue Signaling Dynamics in Tooth Organogenesis. Sci. Signal. 5, ra4 (2012).

Read the Full Text

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Advanced BMP Gene Therapies for Temporal and Spatial Control of Bone Regeneration.
C. G. Wilson, F. M. Martin-Saavedra, N. Vilaboa, and R. T. Franceschi (2013)
Journal of Dental Research 92, 409-417
   Abstract »    Full Text »    PDF »
Intra-epithelial Requirement of Canonical Wnt Signaling for Tooth Morphogenesis.
X. Zhu, P. Zhao, Y. Liu, X. Zhang, J. Fu, H.- M. Ivy Yu, M. Qiu, Y. Chen, W. Hsu, and Z. Zhang (2013)
J. Biol. Chem. 288, 12080-12089
   Abstract »    Full Text »    PDF »
Bridging Decapentaplegic and Wingless signaling in Drosophila wings through repression of naked cuticle by Brinker.
L. Yang, F. Meng, D. Ma, W. Xie, and M. Fang (2013)
Development 140, 413-422
   Abstract »    Full Text »    PDF »
Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.
S. Jia, J. Zhou, Y. Gao, J.-A. Baek, J. F. Martin, Y. Lan, and R. Jiang (2013)
Development 140, 423-432
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882