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Sci. Signal., 10 January 2012
Vol. 5, Issue 206, p. ra4
A Toothsome Circuit
Interactions between two different types of tissue, epithelium and mesenchyme, play important roles in development and cancer. Tooth development is a system for studying epithelial-mesenchymal interactions that is amenable to experimental manipulation. OConnell et al. performed gene expression profiling of developing molar dental tissues in mice and computational analyses to construct a gene regulatory network that identified a key feedback circuit mediated by diffusible signaling molecules of the Wnt and Bmp families. This circuit controls the production of signaling molecules in other pathways and is self-sustaining. The authors validated their circuit in mice with mutations expected to disrupt the Wnt-Bmp signaling pathways. Similar feedback circuits may also operate in epithelial-mesenchymal interactions in other developing organs or in tumors.
Citation: D. J. OConnell, J. W. K. Ho, T. Mammoto, A. Turbe-Doan, J. T. OConnell, P. S. Haseley, S. Koo, N. Kamiya, D. E. Ingber, P. J. Park, R. L. Maas, A Wnt-Bmp Feedback Circuit Controls Intertissue Signaling Dynamics in Tooth Organogenesis. Sci. Signal.5, ra4 (2012).