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Sci. Signal., 17 January 2012
Vol. 5, Issue 207, p. ra6
[DOI: 10.1126/scisignal.2002636]


Editor's Summary

Activating a GAP by Dimerization
Plexins are receptors for semaphorins, a family of axon guidance molecules. The biochemical and structural analyses performed by Wang et al. suggested that semaphorin binding triggered activation of plexin by inducing dimerization. Furthermore, they found that plexins could act as guanosine triphosphatase (GTPase)–activating proteins for the small GTPase Rap and that the ability of semaphorins to trigger the collapse of axonal growth cones required the inactivation of Rap by plexins. Thus, these results provide a plexin-mediated signaling pathway that could be exploited in regenerative therapies for axon-severing injuries.

Citation: Y. Wang, H. He, N. Srivastava, S. Vikarunnessa, Y.-b. Chen, J. Jiang, C. W. Cowan, X. Zhang, Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization. Sci. Signal. 5, ra6 (2012).

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Genetic dissection of plexin signaling in vivo.
T. Worzfeld, J. M. Swiercz, A. Senturk, B. Genz, A. Korostylev, S. Deng, J. Xia, M. Hoshino, J. A. Epstein, A. M. Chan, et al. (2014)
PNAS 111, 2194-2199
   Abstract »    Full Text »    PDF »
Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease.
M. T. Falta, C. Pinilla, D. G. Mack, A. N. Tinega, F. Crawford, M. Giulianotti, R. Santos, G. M. Clayton, Y. Wang, X. Zhang, et al. (2013)
J. Exp. Med. 210, 1403-1418
   Abstract »    Full Text »    PDF »
Neuroimmune Guidance Cue Semaphorin 3E Is Expressed in Atherosclerotic Plaques and Regulates Macrophage Retention.
A. Wanschel, T. Seibert, B. Hewing, B. Ramkhelawon, T. D. Ray, J. M. van Gils, K. J. Rayner, J. E. Feig, E. R. O'Brien, E. A. Fisher, et al. (2013)
Arterioscler Thromb Vasc Biol 33, 886-893
   Abstract »    Full Text »    PDF »
Plexin B1 inhibits MET through direct association and regulates Shp2 expression in melanocytes.
J. Soong and G. Scott (2013)
J. Cell Sci. 126, 688-695
   Abstract »    Full Text »    PDF »
Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin.
Y. Wang, H. G. Pascoe, C. A. Brautigam, H. He, and X. Zhang (2013)
eLife Sci 2, e01279
   Abstract »    Full Text »    PDF »
Semaphorin 4D/Plexin-B1-Mediated M-Ras GAP Activity Regulates Actin-Based Dendrite Remodeling through Lamellipodin.
G.-i. Tasaka, M. Negishi, and I. Oinuma (2012)
J. Neurosci. 32, 8293-8305
   Abstract »    Full Text »    PDF »
Semaphorin Signaling Meets Rap.
J. L. Bos and W.-J. Pannekoek (2012)
Science Signaling 5, pe6
   Abstract »    Full Text »    PDF »

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