Sci. Signal., 31 January 2012
Bypassing TORWithout target of rapamycin (TOR), cells cannot properly integrate nutrient status with cell growth. In yeast, loss of one of the Tor-encoding genes, TOR2, is lethal. Cardon et al. found that phosphorylation of Ugp1 by the yeast PASK (yPASK) family members rescued the growth defect of a temperature-sensitive tor2 yeast mutant. This rescue involved the formation of a multiprotein complex that activated the guanosine triphosphatase Rho1 and was independent of the well-known function of Ugp1 in supplying glucose for cell wall synthesis. This work defines a pathway that provides a pro-growth signal in the absence of Tor2 and shows that yPASK-phosphorylated Ugp1 is a dual-purpose protein, directing glucose to the periphery for cell wall synthesis and activating Rho1 to promote cell growth.
Citation: C. M. Cardon, T. Beck, M. N. Hall, J. Rutter, PAS Kinase Promotes Cell Survival and Growth Through Activation of Rho1. Sci. Signal. 5, ra9 (2012).
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