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Sci. Signal., 21 February 2012
Vol. 5, Issue 212, p. ra16
[DOI: 10.1126/scisignal.2001931]


Editor's Summary

Preventing H5N1 from Damaging Lungs
The higher mortality rate of the H5N1 strain of avian influenza compared to that of the seasonal H1N1 virus is attributed to the more severe lung damage caused by the H5N1 strain. Sun et al. found that lung tissue from an individual infected with H5N1 contained many autophagosomes and that mice infected with H5N1 had greater numbers of autophagosomes in lung tissue than did mice infected with the H1N1 strain. In addition, the H5N1 virus stimulated autophagic signaling in mouse epithelial cells to a greater extent than did the H1N1 virus. Pharmacological inhibition of autophagic signaling or knockdown of components of the autophagy pathway in H5N1-infected mice resulted in less severe lung damage, increased survival rate, and decreased mortality. These findings suggest that targeting the autophagy pathway might provide therapeutic targets in treating H5N1 infection in humans.

Citation: Y. Sun, C. Li, Y. Shu, X. Ju, Z. Zou, H. Wang, S. Rao, F. Guo, H. Liu, W. Nan, Y. Zhao, Y. Yan, J. Tang, C. Zhao, P. Yang, K. Liu, S. Wang, H. Lu, X. Li, L. Tan, R. Gao, J. Song, X. Gao, X. Tian, Y. Qin, K.-F. Xu, D. Li, N. Jin, C. Jiang, Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection. Sci. Signal. 5, ra16 (2012).

Read the Full Text

Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-{kappa}B and p38 MAPK signaling pathways.
H. Pan, Y. Zhang, Z. Luo, P. Li, L. Liu, C. Wang, H. Wang, H. Li, and Y. Ma (2014)
Am J Physiol Lung Cell Mol Physiol 306, L183-L195
   Abstract »    Full Text »    PDF »
Autophagy Benefits the Replication of Newcastle Disease Virus in Chicken Cells and Tissues.
Y. Sun, S. Yu, N. Ding, C. Meng, S. Meng, S. Zhang, Y. Zhan, X. Qiu, L. Tan, H. Chen, et al. (2014)
J. Virol. 88, 525-537
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Influenza A Virus Proteins NS1 and Hemagglutinin Along with M2 Are Involved in Stimulation of Autophagy in Infected Cells.
O. P. Zhirnov and H. D. Klenk (2013)
J. Virol. 87, 13107-13114
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The amazing innate immune response to influenza A virus infection.
S. Tripathi, M. R. White, and K. L. Hartshorn (2013)
Innate Immunity
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Identification of 23-(S)-2-Amino-3-Phenylpropanoyl-Silybin as an Antiviral Agent for Influenza A Virus Infection In Vitro and In Vivo.
J.-P. Dai, L.-Q. Wu, R. Li, X.-F. Zhao, Q.-Y. Wan, X.-X. Chen, W.-Z. Li, G.-F. Wang, and K.-S. Li (2013)
Antimicrob. Agents Chemother. 57, 4433-4443
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Autophagy: a potential therapeutic target in lung diseases.
K. Nakahira and A. M. K. Choi (2013)
Am J Physiol Lung Cell Mol Physiol 305, L93-L107
   Abstract »    Full Text »    PDF »
Impairment of autophagy decreases ventilator-induced lung injury by blockade of the NF-{kappa}B pathway.
I. Lopez-Alonso, A. Aguirre, A. Gonzalez-Lopez, A. F. Fernandez, L. Amado-Rodriguez, A. Astudillo, E. Batalla-Solis, and G. M. Albaiceta (2013)
Am J Physiol Lung Cell Mol Physiol 304, L844-L852
   Abstract »    Full Text »    PDF »
Porcine Circovirus Type 2 Induces Autophagy via the AMPK/ERK/TSC2/mTOR Signaling Pathway in PK-15 Cells.
B. Zhu, Y. Zhou, F. Xu, J. Shuai, X. Li, and W. Fang (2012)
J. Virol. 86, 12003-12012
   Abstract »    Full Text »    PDF »

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