Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 28 February 2012
Vol. 5, Issue 213, p. ra17
[DOI: 10.1126/scisignal.2002449]


Editor's Summary

Genetically Identical, But Not Equally Sensitive
Individual cells of the social amoeba Dictyostelium can organize to form multicellular ensembles, a process in which the chemoattractant cAMP (cyclic adenosine monophosphate) triggers production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) to induce polarization of the chemotaxing cells. Cell population responses have generally been averaged; however, Wang et al. found that not all cells in a group of genetically identical Dictyostelium cells produced PIP3 in response to cAMP and that more cells produced PIP3 as the cAMP concentration increased. Furthermore, modeling and experiments suggested that an amplification step occurred downstream of an adaptive signaling network and that different cells had different amplification thresholds. Different sensitivities and thresholds for signal amplification may enable highly responsive individual cells to promote chemotaxis of an entire population of Dictyostelium cells and, thus, mediate collective behavior.

Citation: C. J. Wang, A. Bergmann, B. Lin, K. Kim, A. Levchenko, Diverse Sensitivity Thresholds in Dynamic Signaling Responses by Social Amoebae. Sci. Signal. 5, ra17 (2012).

Read the Full Text

Microfluidic Platforms for Single-Cell Protein Analysis.
Y. Liu and A. K. Singh (2013)
Journal of Laboratory Automation 18, 446-454
   Abstract »    Full Text »    PDF »
Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture.
H. Chang and A. Levchenko (2013)
Phil Trans R Soc B 368, 20130117
   Abstract »    Full Text »    PDF »
Optical control demonstrates switch-like PIP3 dynamics underlying the initiation of immune cell migration.
W. K. A. Karunarathne, L. Giri, A. K. Patel, K. V. Venkatesh, and N. Gautam (2013)
PNAS 110, E1575-E1583
   Abstract »    Full Text »    PDF »
Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis.
R. Kataria, X. Xu, F. Fusetti, I. Keizer-Gunnink, T. Jin, P. J. M. van Haastert, and A. Kortholt (2013)
PNAS 110, 6424-6429
   Abstract »    Full Text »    PDF »
Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations.
C. Westendorf, J. Negrete Jr., A. J. Bae, R. Sandmann, E. Bodenschatz, and C. Beta (2013)
PNAS 110, 3853-3858
   Abstract »    Full Text »    PDF »
Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm.
N. D. Kashikar, L. Alvarez, R. Seifert, I. Gregor, O. Jackle, M. Beyermann, E. Krause, and U. B. Kaupp (2012)
J. Cell Biol. 198, 1075-1091
   Abstract »    Full Text »    PDF »
Quantifying collective behavior in mammalian cells.
J. C. Conrad (2012)
PNAS 109, 7591-7592
   Full Text »    PDF »
Chemoattractant Signaling in Dictyostelium: Adaptation and Amplification.
P. A. Iglesias (2012)
Science Signaling 5, pe8
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882