Sci. Signal., 13 March 2012
Finding the Hidden Meaning in Disordered RegionsMany proteins, including those involved in signal transduction, have large disordered regions, in addition to their clearly defined domains or motifs. Although these disordered regions are functionally important, identifying the important residues in these regions has proved challenging because the regions are not visualized in crystal structures and tend to exhibit high sequence divergence. Nguyen Ba et al. modified the phylogenetic hidden Markov model so that it could be applied to these disordered regions. Application of this method to yeast proteins not only revealed the presence of known short conserved motifs in proteins not known to have these motifs but also predicted previously unknown short conserved motifs. Experimental analysis suggested that both sets of motifs were functionally important. Thus, this approach should provide an effective method for discovering biologically important conserved motifs within the disordered regions of proteins.
Citation: A. N. Nguyen Ba, B. J. Yeh, D. van Dyk, A. R. Davidson, B. J. Andrews, E. L. Weiss, A. M. Moses, Proteome-Wide Discovery of Evolutionary Conserved Sequences in Disordered Regions. Sci. Signal. 5, rs1 (2012).
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