Sci. Signal., 20 March 2012
Death by CannabinoidsCannabinoid receptors are located in the brain and in the periphery, where they mediate effects on mood, appetite, metabolism, and pain perception. In pancreatic β cells, cannabinoid 1 receptors inhibit insulin action. Kim et al. showed that cannabinoid 1 receptors also prevent prosurvival signaling through the insulin receptor by attenuating its activation. Because loss of β cells through cell death contributes to the decline in pancreatic function seen in both type 1 and type 2 diabetes, pharmacological blockade of the cannabinoid 1 receptor could be developed as a potential therapy for diabetes.
Citation: W. Kim, Q. Lao, Y.-K. Shin, O. D. Carlson, E. K. Lee, M. Gorospe, R. N. Kulkarni, J. M. Egan, Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation. Sci. Signal. 5, ra23 (2012).
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