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Sci. Signal., 24 April 2012
Vol. 5, Issue 221, p. ra33
[DOI: 10.1126/scisignal.2002522]
RESEARCH ARTICLES
Editor's Summary
Biasing β-Arrestin Responses
Activation of the angiotensin type 1 receptor (AT1R) by different ligands can trigger distinct signaling pathways and cellular responses. One such pathway is mediated by the adaptor protein β-arrestin, which can promote cellular proliferation and migration in response to AT1R activation. Zimmerman et al. found that the ability of angiotensin II analogs to enhance β-arrestin–dependent proliferation or migration was linked to distinct conformational changes in β-arrestin induced by the analogs. Thus, biased signaling downstream of the AT1R exists at the level of β-arrestin. These results may help in developing drugs that target specific signaling events triggered by this receptor without affecting others, thereby causing fewer side effects.
Citation: B. Zimmerman, A. Beautrait, B. Aguila, R. Charles, E. Escher, A. Claing, M. Bouvier, S. A. Laporte, Differential β-Arrestin–Dependent Conformational Signaling and Cellular Responses Revealed by Angiotensin Analogs. Sci. Signal.5, ra33 (2012).
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PRESENTATIONS
Petronila Penela, Vanesa Lafarga, Olga Tapia, Verónica Rivas, Laura Nogués, Elisa Lucas, Rocío Vila-Bedmar, Cristina Murga, and Federico Mayor, Jr. (15 May 2012) Sci. Signal.5 (224), pt3.
[DOI: 10.1126/scisignal.2003098] |Abstract »|Full Text »|PDF »|Slideshow »
RESEARCH ARTICLES
Kelly N. Nobles, Kunhong Xiao, Seungkirl Ahn, Arun K. Shukla, Christopher M. Lam, Sudarshan Rajagopal, Ryan T. Strachan, Teng-Yi Huang, Erin A. Bressler, Makoto R. Hara, Sudha K. Shenoy, Steven P. Gygi, and Robert J. Lefkowitz (9 August 2011) Sci. Signal.4 (185), ra51.
[DOI: 10.1126/scisignal.2001707] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
DATABASE OF CELL SIGNALING
Angiotensin II-Stimulated Signaling through G Proteins and beta-Arrestin
Sudha K. Shenoy and Robert J. Lefkowitz Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_16109 |Overview »|Specific Pathway »
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Circ Heart Fail
5, 627-634
|Abstract »|Full Text »|PDF »
