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Sci. Signal., 24 April 2012
Vol. 5, Issue 221, p. ra33
[DOI: 10.1126/scisignal.2002522]


Editor's Summary

Biasing β-Arrestin Responses
Activation of the angiotensin type 1 receptor (AT1R) by different ligands can trigger distinct signaling pathways and cellular responses. One such pathway is mediated by the adaptor protein β-arrestin, which can promote cellular proliferation and migration in response to AT1R activation. Zimmerman et al. found that the ability of angiotensin II analogs to enhance β-arrestin–dependent proliferation or migration was linked to distinct conformational changes in β-arrestin induced by the analogs. Thus, biased signaling downstream of the AT1R exists at the level of β-arrestin. These results may help in developing drugs that target specific signaling events triggered by this receptor without affecting others, thereby causing fewer side effects.

Citation: B. Zimmerman, A. Beautrait, B. Aguila, R. Charles, E. Escher, A. Claing, M. Bouvier, S. A. Laporte, Differential β-Arrestin–Dependent Conformational Signaling and Cellular Responses Revealed by Angiotensin Analogs. Sci. Signal. 5, ra33 (2012).

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