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Sci. Signal., 8 May 2012
Vol. 5, Issue 223, p. ra36
Limiting the Signal Through Macropinocytosis
Fibroblast growth factor 2 (FGF2) triggers migration and proliferation of endothelial cells by binding to fibroblast growth factor receptor 1 (FGFR1) and the co-receptor syndecan 4 (S4). Activation of FGFR1 initiates signaling through mitogen-activated protein kinases (MAPKs). Elfenbein et al. found that S4 decreased the internalization of FGFR1 through a process called macropinocytosis. Furthermore, S4-mediated macropinocytosis of FGFR1 decreased the amplitude and increased the deactivation kinetics of MAPK signaling. Thus, these results indicate that S4 controls the duration of MAPK activation in response to binding of FGF2 to FGFR1.
Citation: A. Elfenbein, A. Lanahan, T. X. Zhou, A. Yamasaki, E. Tkachenko, M. Matsuda, M. Simons, Syndecan 4 Regulates FGFR1 Signaling in Endothelial Cells by Directing Macropinocytosis. Sci. Signal.5, ra36 (2012).
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Effects of Membrane Trafficking on Signaling by Receptor Tyrosine Kinases.